EPO

EPO
Strwythurau PDB Orthologau:PDBe RCSB Rhestr o ddynodwyr PDB 1BUY, 1CN4, 1EER
Dynodwyr
Cyfenwau	EPO, EP, MVCD2, erythropoietin, Erythropoietin, ECYT5, DBAL
Dynodwyr allanol	OMIM: 133170 MGI: 95407 HomoloGene: 624 GeneCards: EPO
Lleoliad y genyn (llygoedn) Cr. Cromosom 5 (llygoden) Band 5 G2|5 76.5 cM Start 137,483,020 bp End 137,533,242 bp
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • hormone activity • protein kinase activator activity • protein binding • erythropoietin receptor binding • cytokine activity Cydrannau o'r gell • extracellular region • cell surface • cell body • extracellular space Prosesau biolegol • erythrocyte maturation • negative regulation of cation channel activity • response to interleukin-1 • response to hypoxia • negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress • response to nutrient • response to salt stress • negative regulation of erythrocyte apoptotic process • response to testosterone • regulation of transcription from RNA polymerase II promoter • response to hyperoxia • positive regulation of Ras protein signal transduction • heneiddio • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • response to electrical stimulus • blood circulation • response to estrogen • cellular hyperosmotic response • positive regulation of transcription, DNA-templated • response to vitamin A • response to lipopolysaccharide • acute-phase response • peptidyl-serine phosphorylation • response to axon injury • hemoglobin biosynthetic process • positive regulation of neuron differentiation • positive regulation of cell proliferation • regulation of transcription from RNA polymerase II promoter in response to hypoxia • positive regulation of ERK1 and ERK2 cascade • positive regulation of neuron projection development • negative regulation of calcium ion transport into cytosol • negative regulation of myeloid cell apoptotic process • activation of protein kinase activity • embryo implantation • signal transduction • positive regulation of activated T cell proliferation • positive regulation of protein kinase activity • negative regulation of neuron death • apoptotic process • response to dexamethasone • cell proliferation • erythrocyte differentiation • erythropoietin-mediated signaling pathway • positive regulation of tyrosine phosphorylation of STAT protein • regulation of receptor activity • positive regulation of phosphatidylinositol 3-kinase signaling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2056	13856
Ensembl	ENSG00000130427	ENSMUSG00000029711
UniProt	P01588	P07321
RefSeq (mRNA)	NM_000799	NM_007942 NM_001312875
RefSeq (protein)	NP_000790	NP_001299804 NP_031968
Lleoliad (UCSC)	n/a	Chr : 137.48 – 137.53 Mb
PubMed search
Wicidata
Gweld/Golygu Bod dynol Gweld/Golygu Llygoden

Protein sy'n cael ei godio yn y corff dynol gan y genyn EPO yw EPO a elwir hefyd yn Erythropoietin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 7, band 7q22.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EPO.

• EP
• MVCD2

Llyfryddiaeth

• "Effect of quercetin on cell protection via erythropoietin and cell injury of HepG2 cells. ". Arch Biochem Biophys. 2017. PMID 29080630.
• "Erythropoietin Induces an Epithelial to Mesenchymal Transition-Like Process in Mammary Epithelial Cells MCF10A. ". J Cell Biochem. 2017. PMID 28247960.
• "Molecular Design, Expression and Evaluation of PASylated Human Recombinant Erythropoietin with Enhanced Functional Properties. ". Protein J. 2017. PMID 28168382.
• "Erythropoietin in Predicting Prognosis in Patients with Acute-on-Chronic Liver Failure. ". J Gastrointestin Liver Dis. 2016. PMID 27981303.
• "Erythropoietin induces production of hepatocyte growth factor from bone marrow mesenchymal stem cells in vitro.". Biologicals. 2017. PMID 27865586.