EPHB2

EPHB2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1B4F, 1F0M, 2QBX, 3ZFM
Dynodwyr
Cyfenwau	EPHB2, Ephb2, Cek5, Drt, ETECK, Erk, Hek5, Nuk, Prkm5, Qek5, Sek3, Tyro5, CAPB, EK5, EPHT3, PCBC, EPH receptor B2, DRT, ERK, BDPLT22
Dynodwyr allanol	OMIM: 600997 HomoloGene: 37925 GeneCards: EPHB2
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • nucleotide binding; • protein kinase activity; • transmembrane-ephrin receptor activity; • kinase activity; • GO:0001948, GO:0016582 protein binding; • identical protein binding; • transmembrane receptor protein tyrosine kinase activity; • protein tyrosine kinase activity; • signaling receptor binding; • ATP binding; • axon guidance receptor activity; • ephrin receptor activity; • amyloid-beta binding; • signaling receptor activity; • GO:0032403 protein-containing complex binding;
Cydrannau o'r gell	• integral component of membrane; • cytosol; • cell projection; • bilen; • integral component of plasma membrane; • extracellular region; • axon; • soma; • dendrite; • cnewyllyn cell; • Cellbilen; • neuron projection; • receptor complex; • postsynapse; • glutamatergic synapse; • integral component of postsynaptic membrane; • integral component of presynaptic membrane;
Prosesau biolegol	• positive regulation of synapse assembly; • roof of mouth development; • phosphorylation; • transmembrane receptor protein tyrosine kinase signaling pathway; • optic nerve morphogenesis; • ephrin receptor signaling pathway; • learning; • commissural neuron axon guidance; • nervous system development; • multicellular organism development; • regulation of axonogenesis; • dendritic spine development; • dendritic spine morphogenesis; • negative regulation of axonogenesis; • protein phosphorylation; • positive regulation of long-term neuronal synaptic plasticity; • regulation of body fluid levels; • inner ear morphogenesis; • angiogenesis; • GO:0000767 cell morphogenesis; • animal organ morphogenesis; • regulation of neuronal synaptic plasticity; • urogenital system development; • peptidyl-tyrosine phosphorylation; • corpus callosum development; • central nervous system projection neuron axonogenesis; • axonal fasciculation; • camera-type eye morphogenesis; • retinal ganglion cell axon guidance; • axon guidance; • trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission; • GO:0033128 negative regulation of protein phosphorylation; • learning or memory; • GO:1901313 positive regulation of gene expression; • positive regulation of synaptic plasticity; • negative regulation of Ras protein signal transduction; • regulation of synapse assembly; • negative regulation of ERK1 and ERK2 cascade; • postsynaptic membrane assembly; • neuron projection retraction; • positive regulation of long-term synaptic potentiation; • positive regulation of protein localization to plasma membrane; • negative regulation of NMDA glutamate receptor activity; • positive regulation of NMDA glutamate receptor activity;
	Sources:Amigo / QuickGO
Orthologau
	2048
	n/a
	ENSG00000133216
	n/a
	P29323
	n/a
	NM_001309192; NM_001309193; NM_004442; NM_017449
	n/a
	NP_001296121; NP_001296122; NP_004433; NP_059145
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EPHB2 yw EPHB2 a elwir hefyd yn EPH receptor B2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p36.12.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EPHB2.

DRT
EK5
ERK
CAPB
Hek5
PCBC
EPHT3
Tyro5

Llyfryddiaeth

"EphrinB-mediated reverse signalling controls junctional integrity and pro-inflammatory differentiation of endothelial cells. ". Thromb Haemost. 2014. PMID 24522257.
"EphB2 promotes cervical cancer progression by inducing epithelial-mesenchymal transition. ". Hum Pathol. 2014. PMID 24439224.
"EPH/ephrin profile and EPHB2 expression predicts patient survival in breast cancer. ". Oncotarget. 2016. PMID 26870995.
"EphB2 activation is required for ependymoma development as well as inhibits differentiation and promotes proliferation of the transformed cell. ". Sci Rep. 2015. PMID 25801123.
"Increased EphB2 expression predicts cholangiocarcinoma metastasis.". Tumour Biol. 2014. PMID 25012246.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] EPHB2 - Cronfa NCBI

[1]

[2]