EPHA7

EPHA7
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2REI, 3DKO, 3H8M, 3NRU
Dynodwyr
Cyfenwau	EPHA7, EHK-3, EHK3, EK11, HEK11, EPH receptor A7
Dynodwyr allanol	OMIM: 602190 HomoloGene: 20935 GeneCards: EPHA7
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • GPI-linked ephrin receptor activity • ephrin receptor binding • kinase activity • GO:0001948, GO:0016582 protein binding • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase activity • ATP binding • axon guidance receptor activity • ephrin receptor activity • chemorepellent activity • receptor tyrosine kinase • transmembrane signaling receptor activity • transmembrane-ephrin receptor activity Cydrannau o'r gell • integral component of membrane • postsynaptic membrane • bilen • neuromuscular junction • Cellbilen • integral component of plasma membrane • neuronal cell body • dendrite • Schaffer collateral - CA1 synapse • hippocampal mossy fiber to CA3 synapse • glutamatergic synapse • integral component of postsynaptic specialization membrane • integral component of postsynaptic density membrane • cytoplasm • neuron projection • receptor complex Prosesau biolegol • GO:0097285 apoptotic process • positive regulation of protein phosphorylation • regulation of protein autophosphorylation • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • ephrin receptor signaling pathway • negative regulation of synapse assembly • regulation of cysteine-type endopeptidase activity involved in apoptotic process • nervous system development • branching morphogenesis of a nerve • multicellular organism development • protein phosphorylation • negative regulation of collateral sprouting • positive regulation of neuron apoptotic process • brain development • nephric duct morphogenesis • regulation of cell-cell adhesion • regulation of ERK1 and ERK2 cascade • positive regulation of apoptotic process • peptidyl-tyrosine phosphorylation • regulation of peptidyl-tyrosine phosphorylation • retinal ganglion cell axon guidance • negative chemotaxis • regulation of postsynapse organization • negative regulation of signal transduction • cell differentiation • negative regulation of apoptotic process • positive regulation of ERK1 and ERK2 cascade • axon guidance Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2045	n/a
Ensembl	ENSG00000135333	n/a
UniProt	Q15375	n/a
RefSeq (mRNA)	NM_001288629 NM_001288630 NM_004440	n/a
RefSeq (protein)	NP_001275558 NP_001275559 NP_004431 NP_001363394 NP_001363395 NP_001363396 NP_001363397 NP_001363398 NP_001363399 NP_001363400	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EPHA7 yw EPHA7 a elwir hefyd yn EPH receptor A7 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6q16.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EPHA7.

• EHK3
• EK11
• EHK-3
• HEK11

Llyfryddiaeth

• "Knockdown of ephrin receptor A7 suppresses the proliferation and metastasis of A549 human lung cancer cells. ". Mol Med Rep. 2016. PMID 26936314.
• "Effect of EphA7 Silencing on Proliferation, Invasion and Apoptosis in Human Laryngeal Cancer Cell Lines Hep-2 and AMC-HN-8. ". Cell Physiol Biochem. 2015. PMID 25968442.
• "[Expression of EphA7 protein in primary hepatocellular carcinoma and its clinical significance]. ". Zhonghua Wai Ke Za Zhi. 2010. PMID 20302756.
• "Secreted form of EphA7 in lung cancer. ". Int J Oncol. 2010. PMID 20126984.
• "Aberrant methylation of EphA7 in human prostate cancer and its relation to clinicopathologic features.". Int J Cancer. 2009. PMID 18821581.