EPHA2

EPHA2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1MQB, 2E8N, 2K9Y, 2KSO, 2X10, 2X11, 3C8X, 3CZU, 3FL7, 3HEI, 3HPN, 3KKA, 3MBW, 3MX0, 3SKJ, 4P2K, 4PDO, 4TRL, 5EK7
Dynodwyr
Cyfenwau	EPHA2, Epha2, AW545284, Eck, Myk2, Sek-2, Sek2, ARCC2, CTPA, CTPP1, CTRCT6, EPH receptor A2, ECK
Dynodwyr allanol	OMIM: 176946 HomoloGene: 20929 GeneCards: EPHA2
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • protein kinase activity; • transferase activity; • kinase activity; • GO:0001948, GO:0016582 protein binding; • protein tyrosine kinase activity; • ATP binding; • ephrin receptor activity; • transmembrane receptor protein tyrosine kinase activity; • cadherin binding; • virus receptor activity; • transmembrane-ephrin receptor activity;
Cydrannau o'r gell	• integral component of membrane; • cell projection; • bilen; • ruffle membrane; • cell junction; • lamellipodium membrane; • leading edge membrane; • focal adhesion; • integral component of plasma membrane; • intracellular anatomical structure; • Cellbilen; • lamellipodium; • cell surface; • neuron projection; • receptor complex; • tight junctions;
Prosesau biolegol	• regulation of lamellipodium assembly; • skeletal system development; • negative regulation of protein kinase B signaling; • cell differentiation; • regulation of cell adhesion mediated by integrin; • protein kinase B signaling; • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity; • phosphorylation; • transmembrane receptor protein tyrosine kinase signaling pathway; • keratinocyte differentiation; • vasculogenesis; • multicellular organism development; • protein phosphorylation; • cell adhesion; • blood vessel development; • notochord morphogenesis; • notochord cell development; • angiogenesis; • intrinsic apoptotic signaling pathway in response to DNA damage; • neural tube development; • neuron differentiation; • notochord; • regulation of ERK1 and ERK2 cascade; • cell chemotaxis; • post-anal tail morphogenesis; • axial mesoderm formation; • response to growth factor; • GO:0022415 viral process; • cell migration; • GO:0097285 apoptotic process; • peptidyl-tyrosine phosphorylation; • osteoclast differentiation; • osteoblast differentiation; • regulation of angiogenesis; • regulation of blood vessel endothelial cell migration; • ephrin receptor signaling pathway; • lens fiber cell morphogenesis; • mammary gland epithelial cell proliferation; • bone remodeling; • branching involved in mammary gland duct morphogenesis; • GO:0032697 negative regulation of cytokine production; • GO:0051637 defense response to Gram-positive bacterium; • negative regulation of lymphangiogenesis; • blood vessel endothelial cell proliferation involved in sprouting angiogenesis; • pericyte cell differentiation; • negative regulation of angiogenesis; • inflammatory response; • negative regulation of chemokine production; • blood vessel morphogenesis; • cAMP metabolic process; • cell motility; • viral entry into host cell; • positive regulation of protein localization to plasma membrane; • axon guidance; • protein localization to plasma membrane; • positive regulation of bicellular tight junction assembly;
	Sources:Amigo / QuickGO
Orthologau
	1969
	n/a
	ENSG00000142627
	n/a
	P29317
	n/a
	NM_004431; NM_001329090
	n/a
	NP_001316019; NP_004422
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EPHA2 yw EPHA2 a elwir hefyd yn EPH receptor A2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p36.13.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EPHA2.

ECK
CTPA
ARCC2
CTPP1
CTRCT6

Llyfryddiaeth[golygu | golygu cod]

"The SAM domain inhibits EphA2 interactions in the plasma membrane. ". Biochim Biophys Acta. 2017. PMID 27776928.
"Silencing Receptor EphA2 Enhanced Sensitivity to Lipoplatinâ„¢ in Lung Tumor and MPM Cells. ". Cancer Invest. 2016. PMID 27438907.
"Ionizing radiation induces EphA2 S897 phosphorylation in a MEK/ERK/RSK-dependent manner. ". Int J Radiat Biol. 2017. PMID 28705041.
"Structural investigation of a C-terminal EphA2 receptor mutant: Does mutation affect the structure and interaction properties of the Sam domain?". Biochim Biophys Acta. 2017. PMID 28602916.
"Targeting EphA2 impairs cell cycle progression and growth of basal-like/triple-negative breast cancers.". Oncogene. 2017. PMID 28581527.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] EPHA2 - Cronfa NCBI

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[2]