EPHA1

EPHA1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2K1K, 2K1L, 3HIL, 3KKA
Dynodwyr
Cyfenwau	EPHA1, Epha1, 5730453L17Rik, AL033318, Eph, Esk, EPHT, EPHT1, EPH receptor A1, EPH
Dynodwyr allanol	OMIM: 179610 HomoloGene: 3835 GeneCards: EPHA1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • protein kinase activity • nucleotide binding • transmembrane-ephrin receptor activity • kinase activity • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase activity • ATP binding • protein kinase binding • ephrin receptor activity • receptor tyrosine kinase • transmembrane signaling receptor activity Cydrannau o'r gell • integral component of membrane • bilen • Cellbilen • integral component of plasma membrane • cytoplasm • neuron projection • receptor complex Prosesau biolegol • somatic stem cell population maintenance • negative regulation of protein kinase activity • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of cell-matrix adhesion • positive regulation of cell migration • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • positive regulation of angiogenesis • protein phosphorylation • cell surface receptor signaling pathway • negative regulation of cell migration • cell adhesion • angiogenesis • positive regulation of cell population proliferation • protein autophosphorylation • peptidyl-tyrosine phosphorylation • substrate adhesion-dependent cell spreading • positive regulation of stress fiber assembly • ephrin receptor signaling pathway • negative regulation of signal transduction • cell differentiation • negative regulation of apoptotic process • positive regulation of ERK1 and ERK2 cascade • axon guidance Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2041	n/a
Ensembl	ENSG00000146904 ENSG00000284816	n/a
UniProt	P21709	n/a
RefSeq (mRNA)	NM_005232	n/a
RefSeq (protein)	NP_005223	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EPHA1 yw EPHA1 a elwir hefyd yn EPH receptor A1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7q34-q35.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EPHA1.

• EPH
• EPHT
• EPHT1

Llyfryddiaeth

• "Erythropoietin-Producing Hepatocellular A1 is an Independent Prognostic Factor for Gastric Cancer. ". Ann Surg Oncol. 2015. PMID 25391265.
• "Dimerization of the EphA1 receptor tyrosine kinase transmembrane domain: Insights into the mechanism of receptor activation. ". Biochemistry. 2014. PMID 25286141.
• "Knockdown of EPHA1Using CRISPR/CAS9 Suppresses Aggressive Properties of Ovarian Cancer Cells. ". Anticancer Res. 2017. PMID 28739735.
• "Knockdown of EPHA1 by CRISPR/CAS9 Promotes Adhesion and Motility of HRT18 Colorectal Carcinoma Cells. ". Anticancer Res. 2016. PMID 26977017.
• "Expression of the EphA1 protein is associated with Fuhrman nuclear grade in clear cell renal cell carcinomas.". Int J Clin Exp Pathol. 2015. PMID 26261568.