EPB41

EPB41
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1GG3, 2RQ1, 3QIJ
Dynodwyr
Cyfenwau	EPB41, erythrocyte membrane protein band 4.1, 4.1R, EL1, HE
Dynodwyr allanol	OMIM: 130500 HomoloGene: 44324 GeneCards: EPB41
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • spectrin binding • structural molecule activity • calmodulin binding • cytoskeletal protein binding • 1-phosphatidylinositol binding • structural constituent of cytoskeleton • GO:0001948, GO:0016582 protein binding • actin binding • protein C-terminus binding • protein N-terminus binding • phosphoprotein binding Cydrannau o'r gell • bilen • cortical cytoskeleton • cell junction • cell cortex • spectrin-associated cytoskeleton • Cytosgerbwd • cnewyllyn cell • cytoplasm • cytosol • cytoplasmic side of plasma membrane • GO:0097483, GO:0097481 postsynaptic density • Cellbilen • cell cortex region • GO:0009327 protein-containing complex • basolateral plasma membrane Prosesau biolegol • positive regulation of protein binding • GO:0033109 cortical actin cytoskeleton organization • actin cytoskeleton organization • actomyosin structure organization • regulation of cell shape • positive regulation of protein localization to cell cortex • cell cycle • Cellraniad • GO:0034622 protein-containing complex assembly • regulation of calcium ion transport • regulation of intestinal absorption Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2035	n/a
Ensembl	ENSG00000159023	n/a
UniProt	P11171	n/a
RefSeq (mRNA)	NM_001166005 NM_001166006 NM_001166007 NM_004437 NM_203342 NM_203343 NM_001376013 NM_001376014 NM_001376015 NM_001376016 NM_001376017 NM_001376018 NM_001376019 NM_001376020 NM_001376021 NM_001376022 NM_001376023 NM_001376024 NM_001376025 NM_001376026 NM_001376027 NM_001376028	n/a
RefSeq (protein)	NP_001159477 NP_001159478 NP_001159479 NP_004428 NP_976217 NP_976218 NP_001362942 NP_001362943 NP_001362944 NP_001362945 NP_001362946 NP_001362947 NP_001362948 NP_001362949 NP_001362950 NP_001362951 NP_001362952 NP_001362953 NP_001362954 NP_001362955 NP_001362956 NP_001362957	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EPB41 yw EPB41 a elwir hefyd yn Erythrocyte membrane protein band 4.1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p35.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EPB41.

• HE
• EL1
• 4.1R

Llyfryddiaeth

• "Alternative polyadenylation in a family of paralogous EPB41 genes generates protein 4.1 diversity. ". RNA Biol. 2017. PMID 27981895.
• "Integrative Functional Genomics Implicates EPB41 Dysregulation in Hepatocellular Carcinoma Risk. ". Am J Hum Genet. 2016. PMID 27453575.
• "Comprehensive characterization of protein 4.1 expression in epithelium of large intestine. ". Histochem Cell Biol. 2014. PMID 24912669.
• "Structural stabilization of protein 4.1R FERM domain upon binding to apo-calmodulin: novel insights into the biological significance of the calcium-independent binding of calmodulin to protein 4.1R. ". Biochem J. 2011. PMID 21848512.
• "Nonsense-mediated mRNA decay (NMD) blockage promotes nonsense mRNA stabilization in protein 4.1R deficient cells carrying the 4.1R Coimbra variant of hereditary elliptocytosis.". Blood Cells Mol Dis. 2010. PMID 20863723.