ELK4

ELK4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1BC7, 1BC8, 1HBX, 1K6O
Dynodwyr
Cyfenwau	ELK4, SAP1, ETS transcription factor, ETS transcription factor ELK4
Dynodwyr allanol	OMIM: 600246 HomoloGene: 1492 GeneCards: ELK4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • sequence-specific DNA binding • chromatin binding • GO:0001104 transcription coregulator activity • GO:0001948, GO:0016582 protein binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • nucleoplasm • cnewyllyn cell • cytosol Prosesau biolegol • histone H3 deacetylation • cell differentiation • GO:0009373 regulation of transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • transcription by RNA polymerase II • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2005	n/a
Ensembl	ENSG00000158711	n/a
UniProt	P28324	n/a
RefSeq (mRNA)	NM_001973 NM_021795	n/a
RefSeq (protein)	NP_001964 NP_068567 NP_068567.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ELK4 yw ELK4 a elwir hefyd yn ELK4, ETS-domain protein (SRF accessory protein 1), isoform CRA_a (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q32.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ELK4.

• SAP1

Llyfryddiaeth

• "Identification of ETS-like transcription factor 4 as a novel androgen receptor target in prostate cancer cells. ". Oncogene. 2008. PMID 18469865.
• "Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. ". Cell. 1994. PMID 8293474.
• "Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element. ". Cell. 1992. PMID 1339307.
• "Cyclin-dependent kinase 2 (CDK2) is a key mediator for EGF-induced cell transformation mediated through the ELK4/c-Fos signaling pathway. ". Oncogene. 2016. PMID 26028036.
• "Chimeric transcript generated by cis-splicing of adjacent genes regulates prostate cancer cell proliferation.". Cancer Discov. 2012. PMID 22719019.