EIF5

EIF5
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2E9H, 2G2K, 2IU1
Dynodwyr
Cyfenwau	EIF5, EIF-5, EIF-5A, eukaryotic translation initiation factor 5, Eukaryotic initiation factor 5
Dynodwyr allanol	OMIM: 601710 HomoloGene: 49610 GeneCards: EIF5
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • translation initiation factor activity • nucleotide binding • translation factor activity, RNA binding • GTP binding • GO:0006184 GTPase activity • GO:0001948, GO:0016582 protein binding • eukaryotic initiation factor eIF2 binding • RNA binding • cadherin binding • GDP-dissociation inhibitor activity Cydrannau o'r gell • cnewyllyn cell • Cellbilen • cytoplasm • cytosol Prosesau biolegol • regulation of translational initiation • protein biosynthesis • GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity • formation of translation preinitiation complex • translational initiation • formation of cytoplasmic translation initiation complex Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1983	n/a
Ensembl	ENSG00000100664	n/a
UniProt	P55010	n/a
RefSeq (mRNA)	NM_183004 NM_001969	n/a
RefSeq (protein)	NP_001960 NP_892116	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EIF5 yw EIF5 a elwir hefyd yn Eukaryotic translation initiation factor 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q32.32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EIF5.

• EIF-5
• EIF-5A

Llyfryddiaeth

• "The crystal structure of the carboxy-terminal domain of human translation initiation factor eIF5. ". J Mol Biol. 2006. PMID 16781736.
• "Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factors. ". Biochemistry. 2006. PMID 16584190.
• "Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5). ". J Biol Chem. 1996. PMID 8663286.
• "Defect in the GTPase activating protein (GAP) function of eIF5 causes repression of GCN4 translation. ". Biochem Biophys Res Commun. 2017. PMID 28385532.
• "Sliding of a 43S ribosomal complex from the recognized AUG codon triggered by a delay in eIF2-bound GTP hydrolysis.". Nucleic Acids Res. 2016. PMID 26717981.