EIF4G1

EIF4G1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1LJ2, 1UG3, 2W97, 4AZA, 4F02
Dynodwyr
Cyfenwau	EIF4G1, EIF-4G1, EIF4F, EIF4G, EIF4GI, P220, PARK18, Eukaryotic translation initiation factor 4 gamma, eukaryotic translation initiation factor 4 gamma 1
Dynodwyr allanol	OMIM: 600495 HomoloGene: 110725 GeneCards: EIF4G1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • translation initiation factor activity • GO:0001948, GO:0016582 protein binding • RNA binding • mRNA binding • ATP binding • translation factor activity, RNA binding • eukaryotic initiation factor 4E binding • translation initiation factor binding • GO:0032947 molecular adaptor activity • cadherin binding • identical protein binding Cydrannau o'r gell • cytosol • bilen • cnewyllyn cell • cytoplasm • polysome • eukaryotic translation initiation factor 4F complex • cytosolic small ribosomal subunit • postsynapse Prosesau biolegol • nuclear-transcribed mRNA poly(A) tail shortening • regulation of mRNA stability • behavioral fear response • positive regulation of neuron differentiation • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • GO:0022415 viral process • regulation of translation • regulation of translational initiation • cap-dependent translational initiation • protein biosynthesis • translational initiation • mitochondrion organization • positive regulation of cell population proliferation • negative regulation of autophagy • negative regulation of peptidyl-threonine phosphorylation • positive regulation of cell growth • GO:0051247, GO:0051200 positive regulation of protein metabolic process • GO:0007571 developmental process • positive regulation of peptidyl-serine phosphorylation • cellular macromolecule biosynthetic process • GO:1905616 regulation of gene silencing by miRNA • GO:1904490 regulation of cellular response to stress • positive regulation of G1/S transition of mitotic cell cycle • negative regulation of neuron death • positive regulation of eukaryotic translation initiation factor 4F complex assembly • regulation of presynapse assembly • positive regulation of mRNA cap binding • regulation of polysome binding • positive regulation of cell death • cellular response to nutrient levels • energy homeostasis • lung development • response to ethanol Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1981	n/a
Ensembl	ENSG00000114867	n/a
UniProt	Q04637	n/a
RefSeq (mRNA)	NM_198244 NM_001194946 NM_001194947 NM_001291157 NM_004953 NM_182917 NM_198241 NM_198242	n/a
RefSeq (protein)	NP_001181875 NP_001181876 NP_001278086 NP_004944 NP_886553 NP_937884 NP_937885 NP_937887	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EIF4G1 yw EIF4G1 a elwir hefyd yn Eukaryotic translation initiation factor 4 gamma 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3q27.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EIF4G1.

• P220
• EIF4F
• EIF4G
• EIF4GI
• PARK18
• EIF-4G1

Llyfryddiaeth

• "An accurately preorganized IRES RNA structure enables eIF4G capture for initiation of viral translation. ". Nat Struct Mol Biol. 2016. PMID 27525590.
• "Eukaryotic translation initiation factor 4-γ, 1 gene mutations are rare in Parkinson's disease among Taiwanese. ". J Formos Med Assoc. 2016. PMID 26490695.
• "EIF4G1 mutations do not cause Parkinson's disease. ". Neurobiol Aging. 2015. PMID 26022768.
• "The EIF4G1 gene and Parkinson's disease. ". Acta Neurol Scand. 2015. PMID 25765080.
• "EIF4G1 is neither a strong nor a common risk factor for Parkinson's disease: evidence from large European cohorts.". J Med Genet. 2015. PMID 25368108.