EIF4A1

EIF4A1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2G9N, 2ZU6, 3EIQ
Dynodwyr
Cyfenwau	EIF4A1, DDX2A, EIF-4A, EIF4A, eIF-4A-I, eIF4A-I, eukaryotic translation initiation factor 4A1
Dynodwyr allanol	OMIM: 602641 HomoloGene: 103998 GeneCards: EIF4A1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • GO:0008026 helicase activity • translation initiation factor activity • translation factor activity, RNA binding • GO:0001948, GO:0016582 protein binding • nucleic acid binding • RNA cap binding • double-stranded RNA binding • hydrolase activity • ATP binding • mRNA binding • RNA binding Cydrannau o'r gell • cytoplasm • cytosol • bilen • eukaryotic translation initiation factor 4F complex • extracellular exosome • cnewyllyn cell • GO:0005578 extracellular matrix Prosesau biolegol • nuclear-transcribed mRNA poly(A) tail shortening • RNA secondary structure unwinding • translational initiation • regulation of gene expression • GO:0022415 viral process • protein biosynthesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1973	n/a
Ensembl	ENSG00000161960	n/a
UniProt	P60842	n/a
RefSeq (mRNA)	NM_001416 NM_001204510	n/a
RefSeq (protein)	NP_001191439 NP_001407	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EIF4A1 yw EIF4A1 a elwir hefyd yn Eukaryotic translation initiation factor 4A1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17p13.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EIF4A1.

• DDX2A
• EIF4A
• EIF-4A
• eIF4A-I
• eIF-4A-I

Llyfryddiaeth

• "RNA BIOCHEMISTRY. Factor-dependent processivity in human eIF4A DEAD-box helicase. ". Science. 2015. PMID 26113725.
• "Eukaryotic initiation factor 4AI interacts with NS4A of Dengue virus and plays an antiviral role. ". Biochem Biophys Res Commun. 2015. PMID 25866185.
• "The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape. ". Cell Death Dis. 2015. PMID 25611378.
• "RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer. ". Nature. 2014. PMID 25079319.
• "Single-molecule kinetics of the eukaryotic initiation factor 4AI upon RNA unwinding.". Structure. 2014. PMID 24909782.