EIF2S1

EIF2S1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1KL9, 1Q8K
Dynodwyr
Cyfenwau	EIF2S1, EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A, eukaryotic translation initiation factor 2 subunit alpha
Dynodwyr allanol	OMIM: 603907 HomoloGene: 3020 GeneCards: EIF2S1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • translation initiation factor activity • ribosome binding • GO:0001948, GO:0016582 protein binding • nucleic acid binding • RNA binding Cydrannau o'r gell • cytoplasm • eukaryotic 48S preinitiation complex • polysome • cytosol • ribosom • bilen • multi-eIF complex • eukaryotic translation initiation factor 2B complex • glial limiting end-foot • translation initiation ternary complex • cytoplasmic stress granule • extracellular exosome • cnewyllyn cell • eukaryotic translation initiation factor 2 complex • synapse Prosesau biolegol • cellular response to heat • positive regulation of type B pancreatic cell apoptotic process • negative regulation of translational initiation in response to stress • cellular response to UV • cellular response to amino acid starvation • GO:0010260 heneiddio • response to endoplasmic reticulum stress • PERK-mediated unfolded protein response • response to manganese-induced endoplasmic reticulum stress • transmembrane transport • translational initiation • protein autophosphorylation • regulation of translation • regulation of translational initiation in response to stress • negative regulation of guanyl-nucleotide exchange factor activity • positive regulation of neuron death • protein biosynthesis • stress granule assembly • cellular response to oxidative stress Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1965	n/a
Ensembl	ENSG00000134001	n/a
UniProt	P05198	n/a
RefSeq (mRNA)	NM_004094	n/a
RefSeq (protein)	NP_004085	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EIF2S1 yw EIF2S1 a elwir hefyd yn Eukaryotic translation initiation factor 2 subunit 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q23.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EIF2S1.

• EIF2
• EIF-2
• EIF2A
• EIF-2A
• EIF-2alpha

Llyfryddiaeth

• "[Pro-survival signaling pathways activated by BCR-ABL oncogene in chronic myelogenous leukemia cells: the role of the perk-EIF2α signal path and acetylation of p53]. ". Postepy Biochem. 2014. PMID 25807820.
• "Residues required for phosphorylation of translation initiation factor eIF2α under diverse stress conditions are divergent between yeast and human. ". Int J Biochem Cell Biol. 2015. PMID 25541374.
• "Translational regulator eIF2α in tumor. ". Tumour Biol. 2014. PMID 24609900.
• "6-Shogaol induces apoptosis in human leukemia cells through a process involving caspase-mediated cleavage of eIF2α. ". Mol Cancer. 2013. PMID 24215632.
• "Eukaryotic initiation factor 2α phosphorylation mediates fetal hemoglobin induction through a post-transcriptional mechanism.". Blood. 2013. PMID 23690448.