EIF2AK3

EIF2AK3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4G31, 4G34, 4M7I, 4X7H, 4X7J, 4X7K, 4X7L, 4X7N, 4X7O, 4YZS
Dynodwyr
Cyfenwau	EIF2AK3, PEK, PERK, WRS, eukaryotic translation initiation factor 2 alpha kinase 3
Dynodwyr allanol	OMIM: 604032 HomoloGene: 3557 GeneCards: EIF2AK3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • protein kinase activity • Hsp90 protein binding • nucleotide binding • protein homodimerization activity • kinase activity • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • identical protein binding • enzyme binding • protein phosphatase binding • ATP binding • eukaryotic translation initiation factor 2alpha kinase activity Cydrannau o'r gell • cytoplasm • integral component of membrane • endoplasmic reticulum membrane • bilen • integral component of endoplasmic reticulum membrane • Reticwlwm endoplasmig • perinuclear region of cytoplasm • cytosolic ribosome Prosesau biolegol • skeletal system development • bone mineralization • insulin-like growth factor receptor signaling pathway • negative regulation of translation • regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation • cellular response to glucose starvation • negative regulation of translation in response to stress • ossification • negative regulation of translational initiation in response to stress • phosphorylation • cellular response to amino acid starvation • chondrocyte development • regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • insulin secretion • endoplasmic reticulum organization • response to endoplasmic reticulum stress • PERK-mediated unfolded protein response • ER overload response • response to manganese-induced endoplasmic reticulum stress • endoplasmic reticulum unfolded protein response • protein phosphorylation • response to unfolded protein • GO:1901313 positive regulation of gene expression • cellular response to cold • GO:0035404 peptidyl-serine phosphorylation • angiogenesis • eiF2alpha phosphorylation in response to endoplasmic reticulum stress • protein autophosphorylation • positive regulation of vascular endothelial growth factor production • positive regulation of transcription by RNA polymerase I • protein homooligomerization • activation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of myelination • regulation of translation • calcium-mediated signaling • endocrine pancreas development • positive regulation of protein localization to nucleus • regulation of translational initiation by eIF2 alpha phosphorylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9451	n/a
Ensembl	ENSG00000172071	n/a
UniProt	Q9NZJ5	n/a
RefSeq (mRNA)	NM_001313915 NM_004836	n/a
RefSeq (protein)	NP_001300844 NP_004827	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EIF2AK3 yw EIF2AK3 a elwir hefyd yn Eukaryotic translation initiation factor 2 alpha kinase 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2p11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EIF2AK3.

• PEK
• WRS
• PERK

Llyfryddiaeth

• "Lipopolysaccharide Induces Autophagic Cell Death through the PERK-Dependent Branch of the Unfolded Protein Response in Human Alveolar Epithelial A549 Cells. ". Cell Physiol Biochem. 2015. PMID 26279443.
• "Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate. ". Cell Death Dis. 2015. PMID 26225772.
• "The ER stress sensor PERK luminal domain functions as a molecular chaperone to interact with misfolded proteins. ". Acta Crystallogr D Struct Biol. 2016. PMID 27917829.
• "Wolcott-Rallison Syndrome with Novel EIF2AK3 Gene Mutation. ". J Clin Res Pediatr Endocrinol. 2016. PMID 27145240.
• "Chemical Genomics Identifies the PERK-Mediated Unfolded Protein Stress Response as a Cellular Target for Influenza Virus Inhibition.". MBio. 2016. PMID 27094326.