EHMT2

EHMT2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2O8J, 3DM1, 3K5K, 3RJW, 4NVQ, 5JJ0, 5JHN, 5JIN
Dynodwyr
Cyfenwau	EHMT2, BAT8, C6orf30, G9A, GAT8, KMT1C, NG36, euchromatic histone lysine methyltransferase 2
Dynodwyr allanol	OMIM: 604599 HomoloGene: 48460 GeneCards: EHMT2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0102674, GO:0102675 methyltransferase activity • transferase activity • histone methyltransferase activity (H3-K9 specific) • promoter-specific chromatin binding • zinc ion binding • C2H2 zinc finger domain binding • histone-lysine N-methyltransferase activity • metal ion binding • histone methyltransferase activity (H3-K27 specific) • protein-lysine N-methyltransferase activity • GO:0001948, GO:0016582 protein binding • p53 binding Cydrannau o'r gell • nucleoplasm • Cromosom • cnewyllyn cell • nuclear speck Prosesau biolegol • regulation of DNA replication • cellular response to starvation • GO:1901227 negative regulation of transcription by RNA polymerase II • DNA methylation • methylation • peptidyl-lysine dimethylation • histone lysine methylation • histone methylation • histone H3-K27 methylation • histone H3-K9 methylation • negative regulation of G0 to G1 transition • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10919	n/a
Ensembl	ENSG00000238134 ENSG00000224143 ENSG00000206376 ENSG00000204371 ENSG00000227333 ENSG00000232045 ENSG00000236759	n/a
UniProt	Q96KQ7	n/a
RefSeq (mRNA)	NM_001289413 NM_006709 NM_025256 NM_001318833 NM_001363689 NM_001395160 NM_001395161 NM_001395162 NM_001395163 NM_001395164 NM_001395165	n/a
RefSeq (protein)	NP_001276342 NP_001305762 NP_006700 NP_079532 NP_001350618	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EHMT2 yw EHMT2 a elwir hefyd yn Histone-lysine N-methyltransferase EHMT2 ac Euchromatic histone lysine methyltransferase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6p21.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EHMT2.

• G9A
• BAT8
• GAT8
• NG36
• KMT1C
• C6orf30

Llyfryddiaeth

• "Mechanism of G9a inhibitor BIX‑01294 acting on U251 glioma cells. ". Mol Med Rep. 2016. PMID 27748874.
• "Depletion of G9a gene induces cell apoptosis in human gastric carcinoma. ". Oncol Rep. 2016. PMID 27081761.
• "G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin. ". Nat Commun. 2017. PMID 28819251.
• "Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3. ". J Hepatol. 2017. PMID 28532996.
• "Histone lysine methyltransferase G9a is a novel epigenetic target for the treatment of hepatocellular carcinoma.". Oncotarget. 2017. PMID 28423509.