EGFR

EGFR
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1IVO, 1M14, 1M17, 1MOX, 1NQL, 1XKK, 1YY9, 1Z9I, 2EB2, 2EB3, 2GS2, 2GS6, 2GS7, 2ITN, 2ITO, 2ITP, 2ITQ, 2ITT, 2ITU, 2ITV, 2ITW, 2ITY, 2ITZ, 2J5E, 2J5F, 2J6M, 2JIT, 2JIU, 2JIV, 2KS1, 2M0B, 2M20, 2RF9, 2RFD, 2RFE, 2RGP, 3B2U, 3B2V, 3BEL, 3BUO, 3C09, 3G5V, 3G5Y, 3GOP, 3GT8, 3IKA, 3LZB, 3NJP, 3OB2, 3OP0, 3P0Y, 3PFV, 3POZ, 3QWQ, 3UG1, 3UG2, 3VJN, 3VJO, 3VRP, 3VRR, 3W2O, 3W2P, 3W2Q, 3W2R, 3W2S, 3W32, 3W33, 4G5J, 4G5P, 4HJO, 4I1Z, 4I20, 4I21, 4I22, 4I23, 4I24, 4JQ7, 4JQ8, 4JR3, 4JRV, 4KRL, 4KRM, 4KRO, 4KRP, 4LI5, 4LL0, 4LQM, 4LRM, 4R3P, 4R3R, 4R5S, 4RIW, 4RIX, 4RIY, 4RJ4, 4RJ5, 4RJ6, 4RJ7, 4RJ8, 4TKS, 4WKQ, 4WRG, 4ZJV, 5CNN, 5CNO, 5CAN, 2N5S, 5CAL, 5C8M, 4UV7, 5CAV, 5CZI, 5EDQ, 5CAS, 5CAO, 5CAP, 5EM5, 5HG5, 5EDR, 5EM8, 5EDP, 5HG7, 5CAU, 5C8K, 5C8N, 5CZH, 5CAQ, 5EM6, 4UIP, 5HG9, 5EM7, 5HG8, 4ZSE, 5HIB, 5HIC, 5D41, 4WD5
Dynodwyr
Cyfenwau	EGFR, ERBB, ERBB1, HER1, NISBD2, PIG61, mENA, epidermal growth factor receptor, Genes, erbB-1, ERRP
Dynodwyr allanol	OMIM: 131550 HomoloGene: 74545 GeneCards: EGFR
Patrwm RNA pattern https://ncbi.nlm.nih.gov/gene?cmd=retrieve&dopt=default&rn=1&list_uids=1956/ Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • kinase activity • nitric-oxide synthase regulator activity • transmembrane receptor protein tyrosine kinase activity • protein phosphatase binding • ATP binding • protein kinase activity • enzyme binding • MAP kinase kinase kinase activity • transferase activity • chromatin binding • actin filament binding • double-stranded DNA binding • transmembrane signaling receptor activity • nucleotide binding • signal transducer activity • identical protein binding • signaling receptor binding • protein tyrosine kinase activity • calmodulin binding • protein kinase binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • protein heterodimerization activity • integrin binding • epidermal growth factor binding • GO:0008313 epidermal growth factor-activated receptor activity • ubiquitin protein ligase binding • cadherin binding • virus receptor activity • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytoplasm • endosome • multivesicular body, internal vesicle lumen • nuclear membrane • bilen • focal adhesion • extracellular region • perinuclear region of cytoplasm • cnewyllyn cell • cell surface • Reticwlwm endoplasmig • integral component of membrane • Golgi apparatus • early endosome membrane • receptor complex • Cellbilen • endocytic vesicle • intracellular anatomical structure • AP-2 adaptor complex • endosome membrane • endoplasmic reticulum membrane • Golgi membrane • basolateral plasma membrane • Shc-EGFR complex • membrane raft • apical plasma membrane • synapse • extracellular space • clathrin-coated vesicle membrane • integral component of plasma membrane • basal plasma membrane • GO:0009327 protein-containing complex Prosesau biolegol • positive regulation of protein phosphorylation • negative regulation of epidermal growth factor receptor signaling pathway • positive regulation of MAP kinase activity • protein phosphorylation • cell surface receptor signaling pathway • protein insertion into membrane • cell population proliferation • morphogenesis of an epithelial fold • ossification • GO:1903363 negative regulation of protein catabolic process • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of fibroblast proliferation • activation of phospholipase C activity • epidermis development • learning or memory • protein autophosphorylation • positive regulation of phosphorylation • cerebral cortex cell migration • digestive tract morphogenesis • hair follicle development • phosphorylation • positive regulation of epithelial cell proliferation • embryonic placenta development • eyelid development in camera-type eye • GO:0043006 activation of phospholipase A2 activity • positive regulation of DNA replication • response to UV-A • regulation of peptidyl-tyrosine phosphorylation • positive regulation of cell migration • positive regulation of nitric oxide biosynthetic process • cellular response to estradiol stimulus • GO:1900404 positive regulation of DNA repair • response to stress • regulation of nitric-oxide synthase activity • salivary gland morphogenesis • MAPK cascade • cellular response to epidermal growth factor stimulus • multicellular organism development • regulation of cell population proliferation • GO:0000767 cell morphogenesis • cellular response to amino acid stimulus • GO:0072468 signal transduction • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • lung development • positive regulation of synaptic transmission, glutamatergic • positive regulation of ERK1 and ERK2 cascade • phosphatidylinositol phosphate biosynthetic process • Rhythm circadaidd • positive regulation of superoxide anion generation • positive regulation of cell population proliferation • positive regulation of vasoconstriction • response to osmotic stress • tongue development • negative regulation of apoptotic process • response to cobalamin • liver regeneration • response to calcium ion • wound healing • cellular response to dexamethasone stimulus • negative regulation of mitotic cell cycle • cellular response to growth factor stimulus • hydrogen peroxide metabolic process • GO:0001306 response to oxidative stress • response to lipid • regulation of cell motility • GO:0007243 intracellular signal transduction • GO:1904578 response to organic cyclic compound • magnesium ion homeostasis • protein biosynthesis • positive regulation of production of miRNAs involved in gene silencing by miRNA • positive regulation of smooth muscle cell proliferation • positive regulation of bone resorption • midgut development • positive regulation of inflammatory response • liver development • diterpenoid metabolic process • ERBB2 signaling pathway • response to estradiol • positive regulation of cell growth • positive regulation of prolactin secretion • astrocyte activation • cellular response to mechanical stimulus • response to hydroxyisoflavone • neuron projection morphogenesis • ovulation cycle • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • peptidyl-tyrosine phosphorylation • membrane organization • positive regulation of protein kinase C activity • negative regulation of ERBB signaling pathway • positive regulation of protein localization to plasma membrane • negative regulation of cardiocyte differentiation • GO:0072353 cellular response to reactive oxygen species • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • regulation of JNK cascade • regulation of ERK1 and ERK2 cascade • cellular response to cadmium ion • positive regulation of NIK/NF-kappaB signaling • viral entry into host cell • epidermal growth factor receptor signaling pathway • positive regulation of peptidyl-serine phosphorylation • peptidyl-tyrosine autophosphorylation • cell-cell adhesion • regulation of phosphatidylinositol 3-kinase signaling • positive regulation of protein kinase B signaling • positive regulation of nitric oxide mediated signal transduction • cell differentiation • positive regulation of cyclin-dependent protein serine/threonine kinase activity • negative regulation of Notch signaling pathway • positive regulation of canonical Wnt signaling pathway • positive regulation of G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1956,https://ncbi.nlm.nih.gov/gene?cmd=retrieve&dopt=default&rn=1&list_uids=1956 1956,https://ncbi.nlm.nih.gov/gene?cmd=retrieve&dopt=default&rn=1&list_uids=1956	n/a
Ensembl	ENSG00000146648	n/a
UniProt	P00533	n/a
RefSeq (mRNA)	NM_001346897 NM_001346898 NM_001346899 NM_001346900 NM_001346941 NM_005228 NM_201282 NM_201283 NM_201284	n/a
RefSeq (protein)	NP_001333826 NP_001333827 NP_001333828 NP_001333829 NP_001333870 NP_005219 NP_958439 NP_958440 NP_958441	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EGFR yw EGFR a elwir hefyd yn Epidermal growth factor receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 7, band 7p11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EGFR.

• ERBB
• HER1
• mENA
• ERBB1
• PIG61
• NISBD2

Llyfryddiaeth

• "Circulating cell-free DNA mutation patterns in early and late stage colon and pancreatic cancer. ". Cancer Genet. 2017. PMID 29153095.
• "Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers. ". Nat Genet. 2017. PMID 29106415.
• "Prognostic implication of EGFR gene mutations and histological classification in patients with resected stage I lung adenocarcinoma. ". PLoS One. 2017. PMID 29065153.
• "Coexistence of two main folded G-quadruplexes within a single G-rich domain in the EGFR promoter. ". Nucleic Acids Res. 2017. PMID 28973461.
• "Clinical validation of a highly sensitive assay to detect EGFR mutations in plasma cell-free DNA from patients with advanced lung adenocarcinoma.". PLoS One. 2017. PMID 28829813.