EFNA1

EFNA1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3HEI, 3MBW, 3CZU
Dynodwyr
Cyfenwau	EFNA1, B61, ECKLG, EFL1, EPLG1, LERK-1, LERK1, TNFAIP4, Ephrin A1, GMAN
Dynodwyr allanol	OMIM: 191164 HomoloGene: 3262 GeneCards: EFNA1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • signaling receptor binding • ephrin receptor binding Cydrannau o'r gell • bilen • Cellbilen • integral component of plasma membrane • anchored component of membrane • extracellular exosome • intracellular anatomical structure • extracellular region • anchored component of plasma membrane Prosesau biolegol • regulation of cell adhesion mediated by integrin • ephrin receptor signaling pathway • aortic valve morphogenesis • cell-cell signaling • GO:1901227 negative regulation of transcription by RNA polymerase II • regulation of angiogenesis • mitral valve morphogenesis • endocardial cushion to mesenchymal transition involved in heart valve formation • regulation of blood vessel endothelial cell migration • regulation of axonogenesis • neuron differentiation • notochord • positive regulation of peptidyl-tyrosine phosphorylation • substrate adhesion-dependent cell spreading • cell migration • negative regulation of epithelial to mesenchymal transition • negative regulation of dendritic spine morphogenesis • regulation of peptidyl-tyrosine phosphorylation • negative regulation of thymocyte apoptotic process • MAPK cascade • angiogenesis • axon guidance • positive regulation of protein phosphorylation • negative regulation of MAPK cascade • positive regulation of MAPK cascade • protein stabilization • positive regulation of protein tyrosine kinase activity • positive regulation of amyloid-beta formation • positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process • negative regulation of proteolysis involved in cellular protein catabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1942	n/a
Ensembl	ENSG00000169242	n/a
UniProt	P20827	n/a
RefSeq (mRNA)	NM_004428 NM_182685	n/a
RefSeq (protein)	NP_004419 NP_872626	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EFNA1 yw EFNA1 a elwir hefyd yn Ephrin A1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q22.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EFNA1.

• B61
• EFL1
• ECKLG
• EPLG1
• LERK1
• LERK-1
• TNFAIP4

Llyfryddiaeth

• "Regulation of endothelial migration and proliferation by ephrin-A1. ". Cell Signal. 2017. PMID 27742560.
• "rs12904 polymorphism in the 3'UTR of EFNA1 is associated with colorectal cancer susceptibility in a Chinese population. ". Asian Pac J Cancer Prev. 2013. PMID 24175772.
• "Ephrin-A1 mRNA is associated with poor prognosis of colorectal cancer. ". Int J Oncol. 2013. PMID 23258614.
• "EphrinA1-EphA2 interaction-mediated apoptosis and FMS-like tyrosine kinase 3 receptor ligand-induced immunotherapy inhibit tumor growth in a breast cancer mouse model. ". J Gene Med. 2012. PMID 22228563.
• "Ephs and ephrins in cancer: ephrin-A1 signalling.". Semin Cell Dev Biol. 2012. PMID 22040911.