EDC3

EDC3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2VC8, 2WAX, 2WAY, 3D3J, 3D3K
Dynodwyr
Cyfenwau	EDC3, LSM16, YJDC, YJEFN2, MRT50, enhancer of mRNA decapping 3, hYjeF_N2-15q23
Dynodwyr allanol	OMIM: 609842 HomoloGene: 11827 GeneCards: EDC3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • phosphodiesterase decapping endonuclease activity • identical protein binding • RNA binding • mRNA binding Cydrannau o'r gell • cytoplasm • cytosol • bilen • P-body • cytoplasmic ribonucleoprotein granule Prosesau biolegol • P-body assembly • exonucleolytic catabolism of deadenylated mRNA • RNA phosphodiester bond hydrolysis, endonucleolytic • deadenylation-independent decapping of nuclear-transcribed mRNA Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	80153	n/a
Ensembl	ENSG00000179151	n/a
UniProt	Q96F86	n/a
RefSeq (mRNA)	NM_001142443 NM_001142444 NM_025083 NM_001351378 NM_001351379	n/a
RefSeq (protein)	NP_001135915 NP_001135916 NP_079359 NP_001338307 NP_001338308	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn EDC3 yw EDC3 a elwir hefyd yn Enhancer of mRNA-decapping protein 3 ac Enhancer of mRNA decapping 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 15, band 15q24.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn EDC3.

• YJDC
• LSM16
• MRT50
• YJEFN2
• hYjeF_N2-15q23

Llyfryddiaeth

• "Crystal structure of human Edc3 and its functional implications. ". Mol Cell Biol. 2008. PMID 18678652.
• "Mutations in DCPS and EDC3 in autosomal recessive intellectual disability indicate a crucial role for mRNA decapping in neurodevelopment. ". Hum Mol Genet. 2015. PMID 25701870.
• "Structure of a Human 4E-T/DDX6/CNOT1 Complex Reveals the Different Interplay of DDX6-Binding Proteins with the CCR4-NOT Complex. ". Cell Rep. 2015. PMID 26489469.
• "Edc3 function in yeast and mammals is modulated by interaction with NAD-related compounds. ". G3 (Bethesda). 2014. PMID 24504254.
• "mRNA decapping factors and the exonuclease Xrn2 function in widespread premature termination of RNA polymerase II transcription.". Mol Cell. 2012. PMID 22483619.