DYNLL1

DYNLL1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1CMI, 3ZKE, 3ZKF, 1F95, 1F3C, 1F96
Dynodwyr
Cyfenwau	DYNLL1, DLC1, DLC8, DNCL1, DNCLC1, LC8, LC8a, PIN, hdlc1, dynein light chain LC8-type 1
Dynodwyr allanol	OMIM: 601562 HomoloGene: 133063 GeneCards: DYNLL1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein domain specific binding • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • cytoskeletal motor activity • cytoskeletal protein binding • plus-end-directed microtubule motor activity • dynein intermediate chain binding • dynein light intermediate chain binding • enzyme binding • nitric-oxide synthase regulator activity • protein homodimerization activity • protein heterodimerization activity • scaffold protein binding Cydrannau o'r gell • cytoplasm • cytosol • centrosome • bilen • Cellbilen • microtubule associated complex • ciliary tip • mitocondria • dynein complex • COP9 signalosome • mitotic spindle • microtubule • Cytosgerbwd • extracellular exosome • cnewyllyn cell • kinetochore • cytoplasmic dynein complex • cilium • tertiary granule membrane • ficolin-1-rich granule membrane • microtubule organizing center • secretory granule • axon cytoplasm Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • substantia nigra development • antigen processing and presentation of exogenous peptide antigen via MHC class II • transcription, DNA-templated • endoplasmic reticulum to Golgi vesicle-mediated transport • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • G2/M transition of mitotic cell cycle • microtubule-based process • intraciliary retrograde transport • GO:0022415 viral process • negative regulation of phosphorylation • macroautophagy • GO:0097285 apoptotic process • intraciliary transport involved in cilium assembly • neutrophil degranulation • motile cilium assembly • ciliary basal body-plasma membrane docking • positive regulation of non-motile cilium assembly • transport along microtubule • cilium assembly • sister chromatid cohesion • regulation of G2/M transition of mitotic cell cycle • GO:0015915 transport • spermatid development • positive regulation of insulin secretion involved in cellular response to glucose stimulus Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8655	n/a
Ensembl	ENSG00000088986	n/a
UniProt	P63167	n/a
RefSeq (mRNA)	NM_003746 NM_001037494 NM_001037495	n/a
RefSeq (protein)	NP_001032583 NP_001032584 NP_003737	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DYNLL1 yw DYNLL1 a elwir hefyd yn Dynein light chain LC8-type 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q24.31.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DYNLL1.

• LC8
• PIN
• DLC1
• DLC8
• LC8a
• DNCL1
• hdlc1
• DNCLC1

Llyfryddiaeth

• "Conformational dynamics promote binding diversity of dynein light chain LC8. ". Biophys Chem. 2011. PMID 21621319.
• "Directed evolution reveals the binding motif preference of the LC8/DYNLL hub protein and predicts large numbers of novel binders in the human proteome. ". PLoS One. 2011. PMID 21533121.
• "Multivalent IDP assemblies: Unique properties of LC8-associated, IDP duplex scaffolds. ". FEBS Lett. 2015. PMID 26226419.
• "Dynein light chain LC8 inhibits osteoclast differentiation and prevents bone loss in mice. ". J Immunol. 2013. PMID 23293355.
• "Dynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientation.". J Cell Biol. 2012. PMID 22965910.