DVL2

DVL2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2REY, 3CBX, 3CBY, 3CBZ, 3CC0, 4WIP
Dynodwyr
Cyfenwau	DVL2, dishevelled segment polarity protein 2
Dynodwyr allanol	OMIM: 602151 HomoloGene: 20927 GeneCards: DVL2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein-macromolecule adaptor activity • protein domain specific binding • GO:0005110 frizzled binding • protein self-association • GO:0001948, GO:0016582 protein binding • identical protein binding • protein kinase binding Cydrannau o'r gell • bilen • clathrin-coated endocytic vesicle • Cellbilen • apical part of cell • clathrin-coated vesicle • cytoplasm • GO:0016023 cytoplasmic vesicle • cnewyllyn cell • cytosol • nucleoplasm • aggresome • lateral plasma membrane • nuclear body Prosesau biolegol • non-canonical Wnt signaling pathway • positive regulation of protein phosphorylation • GO:0007243 intracellular signal transduction • positive regulation of protein tyrosine kinase activity • heart morphogenesis • canonical Wnt signaling pathway involved in regulation of cell proliferation • positive regulation of DNA-binding transcription factor activity • transcription by RNA polymerase II • hippo signaling • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • multicellular organism development • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • protein complex oligomerization • cochlea morphogenesis • convergent extension involved in neural plate elongation • negative regulation of canonical Wnt signaling pathway • segmentation • convergent extension involved in organogenesis • positive regulation of canonical Wnt signaling pathway • neural tube closure • heart development • Wnt signaling pathway • outflow tract morphogenesis • canonical Wnt signaling pathway • segment specification • positive regulation of JUN kinase activity • planar cell polarity pathway involved in neural tube closure • Wnt signaling pathway, planar cell polarity pathway • beta-catenin destruction complex disassembly • membrane organization • positive regulation of neuron projection arborization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1856	n/a
Ensembl	ENSG00000004975	n/a
UniProt	O14641	n/a
RefSeq (mRNA)	NM_004422	n/a
RefSeq (protein)	NP_004413	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DVL2 yw DVL2 a elwir hefyd yn Segment polarity protein dishevelled homolog DVL-2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17p13.1.

Llyfryddiaeth

• "Inhibition of disheveled-2 resensitizes cisplatin-resistant lung cancer cells through down-regulating Wnt/β-catenin signaling. ". Exp Cell Res. 2016. PMID 27432651.
• "Overexpression of Dishevelled-2 contributes to proliferation and migration of human esophageal squamous cell carcinoma. ". J Mol Histol. 2016. PMID 27083564.
• "Expression patterns of dishevelled-2 in different colon tissue segments in Hirschsprung's disease. ". Mol Med Rep. 2015. PMID 25395054.
• "Dishevelled-2 silencing reduces androgen-dependent prostate tumor cell proliferation and migration and expression of Wnt-3a and matrix metalloproteinases. ". Mol Biol Rep. 2013. PMID 23652996.
• "Dishevelled 2 signaling promotes self-renewal and tumorigenicity in human gliomas.". Cancer Res. 2011. PMID 21990322.