DUSP6

DUSP6
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1HZM, 1MKP
Dynodwyr
Cyfenwau	DUSP6, HH19, MKP3, PYST1, dual specificity phosphatase 6
Dynodwyr allanol	OMIM: 602748 HomoloGene: 55621 GeneCards: DUSP6
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phosphoprotein phosphatase activity • GO:0098519, GO:0098518 phosphatase activity • hydrolase activity • MAP kinase tyrosine/serine/threonine phosphatase activity • protein tyrosine phosphatase activity • protein tyrosine/serine/threonine phosphatase activity Cydrannau o'r gell • nucleoplasm • cytosol • cytoplasm Prosesau biolegol • GO:0033128 negative regulation of protein phosphorylation • cell differentiation • positive regulation of cell death • GO:1904578 response to organic cyclic compound • regulation of fibroblast growth factor receptor signaling pathway • GO:0016576 protein dephosphorylation • response to organic substance • MAPK cascade • response to nitrosative stress • positive regulation of apoptotic process • negative regulation of ERK1 and ERK2 cascade • peptidyl-tyrosine dephosphorylation • response to growth factor • dorsal/ventral pattern formation • regulation of endodermal cell fate specification • GO:0098501, GO:0098502, GO:0006286 dephosphorylation • regulation of heart growth Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1848	n/a
Ensembl	ENSG00000139318	n/a
UniProt	Q16828	n/a
RefSeq (mRNA)	NM_022652 NM_001946	n/a
RefSeq (protein)	NP_001937 NP_073143	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DUSP6 yw DUSP6 a elwir hefyd yn Dual specificity phosphatase 6 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q21.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DUSP6.

• HH19
• MKP3
• PYST1

Llyfryddiaeth

• "Systematic screening of isogenic cancer cells identifies DUSP6 as context-specific synthetic lethal target in melanoma. ". Oncotarget. 2017. PMID 28423600.
• "Dual Specificity Phosphatase 6 (DUSP6) Polymorphism Predicts Prognosis of Inoperable Non-Small Cell Lung Cancer after Chemoradiotherapy. ". Clin Lab. 2016. PMID 27156317.
• "Dual-specificity phosphatase 6 predicts the sensitivity of progestin therapy for atypical endometrial hyperplasia. ". Gynecol Oncol. 2015. PMID 25451692.
• "Prognostic value of dual-specificity phosphatase 6 expression in non-small cell lung cancer. ". Tumour Biol. 2015. PMID 25344212.
• "Dual specificity phosphatase 6 suppresses the growth and metastasis of prostate cancer cells.". Mol Med Rep. 2014. PMID 25241655.