DUSP3

DUSP3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1J4X, 1VHR, 3F81
Dynodwyr
Cyfenwau	DUSP3, VHR, dual specificity phosphatase 3
Dynodwyr allanol	OMIM: 600183 HomoloGene: 20870 GeneCards: DUSP3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phosphoprotein phosphatase activity • MAP kinase phosphatase activity • hydrolase activity • protein kinase binding • protein tyrosine/serine/threonine phosphatase activity • GO:0098519, GO:0098518 phosphatase activity • protein tyrosine phosphatase activity • cytoskeletal protein binding • receptor tyrosine kinase binding • protein tyrosine kinase binding Cydrannau o'r gell • cytosol • nucleoplasm • immunological synapse • cnewyllyn cell Prosesau biolegol • GO:0016576 protein dephosphorylation • positive regulation of mitotic cell cycle • negative regulation of T cell receptor signaling pathway • negative regulation of JNK cascade • negative regulation of MAPK cascade • negative regulation of ERK1 and ERK2 cascade • peptidyl-tyrosine dephosphorylation • negative regulation of T cell activation • in utero embryonic development • GO:0098501, GO:0098502, GO:0006286 dephosphorylation • negative regulation of cell migration • negative regulation of epidermal growth factor receptor signaling pathway • negative regulation of chemotaxis • regulation of focal adhesion assembly • cellular response to epidermal growth factor stimulus • positive regulation of focal adhesion disassembly • peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1845	n/a
Ensembl	ENSG00000108861	n/a
UniProt	P51452	n/a
RefSeq (mRNA)	NM_004090	n/a
RefSeq (protein)	NP_004081	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DUSP3 yw DUSP3 a elwir hefyd yn Dual specificity phosphatase 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q21.31.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DUSP3.

• VHR

Llyfryddiaeth

• "Loss of DUSP3 activity radiosensitizes human tumor cell lines via attenuation of DNA repair pathways. ". Biochim Biophys Acta. 2017. PMID 28389334.
• "Reduced levels of Dusp3/Vhr phosphatase impair normal spindle bipolarity in an Erk1/2 activity-dependent manner. ". FEBS Lett. 2016. PMID 27423135.
• "Unnatural amino acid mutagenesis reveals dimerization as a negative regulatory mechanism of VHR's phosphatase activity. ". ACS Chem Biol. 2014. PMID 24798147.
• "Proteomic, cellular, and network analyses reveal new DUSP3 interactions with nucleolar proteins in HeLa cells. ". J Proteome Res. 2013. PMID 24245651.
• "A genetically encoded sulfotyrosine for VHR function research.". Protein Cell. 2013. PMID 23918168.