DUSP22

DUSP22
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1WRM, 4WOH
Dynodwyr
Cyfenwau	DUSP22, JKAP, JSP-1, JSP1, LMW-DSP2, LMWDSP2, MKP-x, MKPX, VHX, dual specificity phosphatase 22
Dynodwyr allanol	OMIM: 616778 HomoloGene: 86039 GeneCards: DUSP22
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein tyrosine phosphatase activity • GO:0098519, GO:0098518 phosphatase activity • phosphoprotein phosphatase activity • hydrolase activity • protein tyrosine/serine/threonine phosphatase activity • non-membrane spanning protein tyrosine phosphatase activity • protein tyrosine kinase binding Cydrannau o'r gell • cytoplasm • cnewyllyn cell • cytosol • Cellbilen • filamentous actin • leading edge of lamellipodium Prosesau biolegol • multicellular organism development • negative regulation of T cell mediated immunity • GO:0016576 protein dephosphorylation • peptidyl-tyrosine dephosphorylation • cell population proliferation • negative regulation of T cell activation • GO:1901227 negative regulation of transcription by RNA polymerase II • transforming growth factor beta receptor signaling pathway • regulation of cell population proliferation • positive regulation of JNK cascade • negative regulation of T cell receptor signaling pathway • GO:0098501, GO:0098502, GO:0006286 dephosphorylation • GO:0097285 apoptotic process • negative regulation of cell migration • negative regulation of focal adhesion assembly • cellular response to epidermal growth factor stimulus • negative regulation of non-membrane spanning protein tyrosine kinase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	56940	n/a
Ensembl	ENSG00000112679	n/a
UniProt	Q9NRW4	n/a
RefSeq (mRNA)	NM_001286555 NM_020185	n/a
RefSeq (protein)	NP_001273484 NP_064570	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DUSP22 yw DUSP22 a elwir hefyd yn Dual specificity phosphatase 22 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p25.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DUSP22.

• VHX
• JKAP
• JSP1
• MKPX
• JSP-1
• MKP-x
• LMWDSP2
• LMW-DSP2

Llyfryddiaeth

• "Primary cutaneous CD30-positive T-cell lymphoproliferative disorders with biallelic rearrangements of DUSP22. ". J Invest Dermatol. 2013. PMID 23337887.
• "Hypomethylation of dual specificity phosphatase 22 promoter correlates with duration of service in firefighters and is inducible by low-dose benzo[a]pyrene. ". J Occup Environ Med. 2012. PMID 22796920.
• "Decreased expression of dual specificity phosphatase 22 in colorectal cancer and its potential prognostic relevance for stage IV CRC patients. ". Tumour Biol. 2015. PMID 26032091.
• "Structural analysis of human dual-specificity phosphatase 22 complexed with a phosphotyrosine-like substrate. ". Acta Crystallogr F Struct Biol Commun. 2015. PMID 25664796.
• "Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer's disease.". Hippocampus. 2014. PMID 24436131.