DUSP2

DUSP2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1M3G
Dynodwyr
Cyfenwau	DUSP2, PAC-1, PAC1, dual specificity phosphatase 2
Dynodwyr allanol	OMIM: 603068 HomoloGene: 3255 GeneCards: DUSP2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein tyrosine phosphatase activity • GO:0098519, GO:0098518 phosphatase activity • MAP kinase tyrosine/serine/threonine phosphatase activity • protein tyrosine/threonine phosphatase activity • GO:0001948, GO:0016582 protein binding • phosphoprotein phosphatase activity • hydrolase activity • protein tyrosine/serine/threonine phosphatase activity • mitogen-activated protein kinase binding Cydrannau o'r gell • cnewyllyn cell • nuclear membrane • cytoplasm Prosesau biolegol • GO:0016576 protein dephosphorylation • endoderm formation • GO:0098501, GO:0098502, GO:0006286 dephosphorylation • peptidyl-tyrosine dephosphorylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1844	n/a
Ensembl	ENSG00000158050	n/a
UniProt	Q05923	n/a
RefSeq (mRNA)	NM_004418	n/a
RefSeq (protein)	NP_004409	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DUSP2 yw DUSP2 a elwir hefyd yn Dual specificity phosphatase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DUSP2.

• PAC1
• PAC-1

Llyfryddiaeth

• "Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon Cancer Stemness. ". Cancer Res. 2017. PMID 28652251.
• "Suppression of dual-specificity phosphatase-2 by hypoxia increases chemoresistance and malignancy in human cancer cells. ". J Clin Invest. 2011. PMID 21490398.
• "Characterization of a variant of PAC-1 in large granular lymphocyte leukemia. ". Protein Expr Purif. 2003. PMID 14680939.
• "Solution structure of the MAPK phosphatase PAC-1 catalytic domain. Insights into substrate-induced enzymatic activation of MKP. ". Structure. 2003. PMID 12575935.
• "Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1.". Nature. 1994. PMID 8107850.