DUSP19

DUSP19
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3S4E, 4D3P, 4D3R, 4D3Q
Dynodwyr
Cyfenwau	DUSP19, DUSP17, LMWDSP3, SKRP1, TS-DSP1, dual specificity phosphatase 19
Dynodwyr allanol	OMIM: 611437 HomoloGene: 41565 GeneCards: DUSP19
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phosphoprotein phosphatase activity • MAP-kinase scaffold activity • mitogen-activated protein kinase kinase kinase binding • GO:0098519, GO:0098518 phosphatase activity • protein kinase inhibitor activity • protein kinase activator activity • GO:0001948, GO:0016582 protein binding • protein tyrosine phosphatase activity • hydrolase activity • protein tyrosine/serine/threonine phosphatase activity • JUN kinase phosphatase activity Cydrannau o'r gell • cytoplasm Prosesau biolegol • negative regulation of protein kinase activity • positive regulation of JUN kinase activity • GO:0016576 protein dephosphorylation • positive regulation of JNK cascade • negative regulation of JNK cascade • peptidyl-tyrosine dephosphorylation • negative regulation of JUN kinase activity • positive regulation of MAPK cascade • positive regulation of protein kinase activity • GO:0098501, GO:0098502, GO:0006286 dephosphorylation • activation of protein kinase activity • regulation of MAP kinase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	142679	n/a
Ensembl	ENSG00000162999	n/a
UniProt	Q8WTR2	n/a
RefSeq (mRNA)	NM_001142314 NM_080876 NM_001321519	n/a
RefSeq (protein)	NP_001135786 NP_001308448 NP_543152	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DUSP19 yw DUSP19 a elwir hefyd yn Dual specificity phosphatase 19 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q32.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DUSP19.

• SKRP1
• DUSP17
• LMWDSP3
• TS-DSP1

Llyfryddiaeth

• "DUSP19, a downstream effector of leptin, inhibits chondrocyte apoptosis via dephosphorylating JNK during osteoarthritis pathogenesis. ". Mol Biosyst. 2016. PMID 26751999.
• "A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway. ". J Biol Chem. 2002. PMID 11959861.
• "Crystal structure of a novel mitogen-activated protein kinase phosphatase, SKRP1. ". Proteins. 2011. PMID 21989941.
• "Molecular cloning and characterization of a novel human protein phosphatase, LMW-DSP3. ". Int J Biochem Cell Biol. 2003. PMID 12479873.
• "Dual-specificity phosphatases: critical regulators with diverse cellular targets.". Biochem J. 2009. PMID 19228121.