DUSP10

DUSP10
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1ZZW, 2OUC, 2OUD, 3TG1
Dynodwyr
Cyfenwau	DUSP10, MKP-5, MKP5, dual specificity phosphatase 10
Dynodwyr allanol	OMIM: 608867 HomoloGene: 5215 GeneCards: DUSP10
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0098519, GO:0098518 phosphatase activity • protein tyrosine phosphatase activity • MAP kinase tyrosine/serine/threonine phosphatase activity • hydrolase activity • protein tyrosine/serine/threonine phosphatase activity • JUN kinase binding • MAP kinase phosphatase activity • mitogen-activated protein kinase p38 binding • phosphoprotein phosphatase activity • protein tyrosine/threonine phosphatase activity • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • Golgi apparatus • nucleoplasm • cytosol • nuclear speck • cnewyllyn cell • cytoplasm Prosesau biolegol • regulation of innate immune response • regulation of adaptive immune response • oligodendrocyte differentiation • negative regulation of respiratory burst involved in inflammatory response • response to organic substance • response to lipopolysaccharide • negative regulation of oligodendrocyte differentiation • negative regulation of protein kinase activity by regulation of protein phosphorylation • negative regulation of stress-activated MAPK cascade • regulation of brown fat cell differentiation • GO:0098501, GO:0098502, GO:0006286 dephosphorylation • positive regulation of regulatory T cell differentiation • GO:0016576 protein dephosphorylation • negative regulation of epithelial cell migration • negative regulation of cell migration • peptidyl-threonine dephosphorylation • negative regulation of JUN kinase activity • negative regulation of JNK cascade • negative regulation of epithelial cell proliferation • negative regulation of ERK1 and ERK2 cascade • negative regulation of p38MAPK cascade • negative regulation of epithelium regeneration • peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11221	n/a
Ensembl	n/a	n/a
UniProt	Q9Y6W6	n/a
RefSeq (mRNA)	NM_007207 NM_144728 NM_144729	n/a
RefSeq (protein)	NP_009138	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DUSP10 yw DUSP10 a elwir hefyd yn Dual specificity phosphatase 10 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q41.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DUSP10.

• MKP5
• MKP-5

Llyfryddiaeth

• "Crystal structure of the MAP kinase binding domain and the catalytic domain of human MKP5. ". Protein Sci. 2007. PMID 17400920.
• "Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells. ". Carcinogenesis. 2007. PMID 17151092.
• "Polymorphisms in the DUSP10 gene are associated with sex-specific colorectal cancer risk in a Han population. ". Int J Clin Exp Pathol. 2015. PMID 25973098.
• "DUSP10 gene polymorphism and risk of colorectal cancer in the Han Chinese population. ". Eur J Cancer Prev. 2014. PMID 23872954.
• "Novel function of MKP-5/DUSP10, a phosphatase of stress-activated kinases, on ERK-dependent gene expression, and upregulation of its gene expression in colon carcinomas.". Oncol Rep. 2012. PMID 22711061.