DRAP1

DRAP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1JFI
Dynodwyr
Cyfenwau	DRAP1, NC2-alpha, DR1 associated protein 1
Dynodwyr allanol	OMIM: 602289 HomoloGene: 4703 GeneCards: DRAP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein heterodimerization activity • GO:0001948, GO:0016582 protein binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001106 transcription corepressor activity • DNA binding • identical protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • chromatin binding • GO:0001105 transcription coactivator activity • transcription factor binding • GO:0001104 transcription coregulator activity Cydrannau o'r gell • cnewyllyn cell Prosesau biolegol • transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:0009373 regulation of transcription, DNA-templated • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • RNA polymerase II preinitiation complex assembly Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10589	n/a
Ensembl	ENSG00000175550	n/a
UniProt	Q14919	n/a
RefSeq (mRNA)	NM_006442	n/a
RefSeq (protein)	NP_006433	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DRAP1 yw DRAP1 a elwir hefyd yn DR1 associated protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q13.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DRAP1.

• NC2-alpha

Llyfryddiaeth

• "The C-terminal domain-phosphorylated IIO form of RNA polymerase II is associated with the transcription repressor NC2 (Dr1/DRAP1) and is required for transcription activation in human nuclear extracts. ". Proc Natl Acad Sci U S A. 2000. PMID 10852970.
• "Regulation of nuclear import and export of negative cofactor 2. ". J Biol Chem. 2009. PMID 19204005.
• "NC2 mobilizes TBP on core promoter TATA boxes. ". Nat Struct Mol Biol. 2007. PMID 17994103.
• "Global distribution of negative cofactor 2 subunit-alpha on human promoters. ". Proc Natl Acad Sci U S A. 2007. PMID 17548813.
• "Hypoxia actively represses transcription by inducing negative cofactor 2 (Dr1/DrAP1) and blocking preinitiation complex assembly.". J Biol Chem. 2003. PMID 12477712.