DR1

DR1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1JFI
Dynodwyr
Cyfenwau	DR1, NC2, NC2-BETA, NC2B, down-regulator of transcription 1, NCB2
Dynodwyr allanol	OMIM: 601482 HomoloGene: 38809 GeneCards: DR1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • TBP-class protein binding • DNA binding • transcription factor binding • GO:0001948, GO:0016582 protein binding • GO:0001106 transcription corepressor activity • protein heterodimerization activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001105 transcription coactivator activity • GO:0000983 RNA polymerase II general transcription initiation factor activity Cydrannau o'r gell • cnewyllyn cell • negative cofactor 2 complex Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • GO:1901227 negative regulation of transcription by RNA polymerase II • histone H3 acetylation • transcription, DNA-templated • chromatin remodeling • regulation of RNA polymerase II transcription preinitiation complex assembly • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • RNA polymerase II preinitiation complex assembly • transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1810	n/a
Ensembl	ENSG00000117505	n/a
UniProt	Q01658	n/a
RefSeq (mRNA)	NM_001938	n/a
RefSeq (protein)	NP_001929	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DR1 yw DR1 a elwir hefyd yn Down-regulator of transcription 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p22.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DR1.

• NC2
• NC2B
• NCB2
• NC2-BETA

Llyfryddiaeth

• "The effect and mechanism of dopamine D1 receptors on the proliferation of osteosarcoma cells. ". Mol Cell Biochem. 2017. PMID 28181134.
• "A host susceptibility gene, DR1, facilitates influenza A virus replication by suppressing host innate immunity and enhancing viral RNA replication. ". J Virol. 2015. PMID 25589657.
• "Basal core promoters control the equilibrium between negative cofactor 2 and preinitiation complexes in human cells. ". Genome Biol. 2010. PMID 20230619.
• "Dr1 (NC2) is present at tRNA genes and represses their transcription in human cells. ". Nucleic Acids Res. 2010. PMID 19965767.
• "Involvement of GTA protein NC2beta in neuroblastoma pathogenesis suggests that it physiologically participates in the regulation of cell proliferation.". Mol Cancer. 2008. PMID 18538002.