DPYD

DPYD
Dynodwyr
Cyfenwau	DPYD, DHP, DHPDHASE, DPD, dihydropyrimidine dehydrogenase, DYPD
Dynodwyr allanol	OMIM: 612779 HomoloGene: 85 GeneCards: DPYD
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • oxidoreductase activity, acting on the CH-CH group of donors • 4 iron, 4 sulfur cluster binding • nucleotide binding • protein homodimerization activity • flavin adenine dinucleotide binding • dihydropyrimidine dehydrogenase (NADP+) activity • iron-sulfur cluster binding • metal ion binding • GO:0001948, GO:0016582 protein binding • catalytic activity • NADP binding • oxidoreductase activity • uracil binding • NADH dehydrogenase activity • dihydropyrimidine dehydrogenase (NAD+) activity Cydrannau o'r gell • cytoplasm • cytosol Prosesau biolegol • beta-alanine biosynthetic process • uracil catabolic process • pyrimidine nucleoside catabolic process • pyrimidine nucleobase catabolic process • thymidine catabolic process • purine nucleobase catabolic process • thymine catabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1806	n/a
Ensembl	ENSG00000188641	n/a
UniProt	Q12882	n/a
RefSeq (mRNA)	NM_000110 NM_001160301	n/a
RefSeq (protein)	NP_000101 NP_001153773	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DPYD yw DPYD a elwir hefyd yn Dihydropyrimidine dehydrogenase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p21.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DPYD.

• DHP
• DPD
• DHPDHASE

Llyfryddiaeth

• "Dihydropyrimidine dehydrogenase pharmacogenetics for predicting fluoropyrimidine-related toxicity in the randomised, phase III adjuvant TOSCA trial in high-risk colon cancer patients. ". Br J Cancer. 2017. PMID 29065426.
• "Capecitabine-based treatment of a patient with a novel DPYD genotype and complete dihydropyrimidine dehydrogenase deficiency. ". Int J Cancer. 2018. PMID 28929491.
• "Fluoropyrimidine-Associated Toxicity in Two Gastrointestinal Cancer Patients: Potential Role of Common DPYD Polymorphisms. ". Chemotherapy. 2017. PMID 28614820.
• "New advances in DPYD genotype and risk of severe toxicity under capecitabine. ". PLoS One. 2017. PMID 28481884.
• "The Impact of the Expression Level of Intratumoral Dihydropyrimidine Dehydrogenase on Chemotherapy Sensitivity and Survival of Patients in Gastric Cancer: A Meta-Analysis.". Dis Markers. 2017. PMID 28255193.