DOT1L

Oddi ar Wicipedia
Jump to navigation Jump to search
DOT1L
Protein DOT1L PDB 1nw3.png
Strwythurau
PDBHuman UniProt search: PDBe RCSB
Dynodwyr
CyfenwauDOT1L, DOT1, KMT4, DOT1 like histone lysine methyltransferase
Dynodwyr allanolOMIM: 607375 HomoloGene: 32779 GeneCards: DOT1L
Patrwm RNA pattern
PBB GE DOT1L 214865 at fs.png
Rhagor o gyfeiriadau
Orthologau
SpeciesBod dynolLlygoden
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032482

n/a

RefSeq (protein)

NP_115871

n/a

Lleoliad (UCSC)n/an/a
PubMed search[1]n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DOT1L yw DOT1L a elwir hefyd yn Histone-lysine N-methyltransferase, H3 lysine-79-specific a Histone-lysine N-methyltransferase, H3 lysine-79 specific (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19p13.3.[2]

Cyfystyron[golygu | golygu cod y dudalen]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DOT1L.

  • DOT1
  • KMT4

Llyfryddiaeth[golygu | golygu cod y dudalen]

  • "Exploring drug delivery for the DOT1L inhibitor pinometostat (EPZ-5676): Subcutaneous administration as an alternative to continuous IV infusion, in the pursuit of an epigenetic target. ". J Control Release. 2015. PMID 26385168.
  • "Degree of recruitment of DOT1L to MLL-AF9 defines level of H3K79 Di- and tri-methylation on target genes and transformation potential. ". Cell Rep. 2015. PMID 25921540.
  • "MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia. ". Cell Rep. 2017. PMID 28076791.
  • "Identification of Novel Disruptor of Telomeric Silencing 1-like (DOT1L) Inhibitors through Structure-Based Virtual Screening and Biological Assays. ". J Chem Inf Model. 2016. PMID 26914852.
  • "Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation.". Nat Commun. 2016. PMID 26830124.

Cyfeiriadau[golygu | golygu cod y dudalen]

  1. "Human PubMed Reference:".
  2. DOT1L - Cronfa NCBI