DOCK2

DOCK2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2RQR, 2YIN, 3A98, 3B13
Dynodwyr
Cyfenwau	DOCK2, IMD40, Dock2, dedicator of cytokinesis 2
Dynodwyr allanol	OMIM: 603122 HomoloGene: 37984 GeneCards: DOCK2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • guanyl-nucleotide exchange factor activity • GO:0001948, GO:0016582 protein binding • T cell receptor binding Cydrannau o'r gell • cytoplasm • cytosol • bilen • extracellular exosome • Cytosgerbwd • endomembrane system • extracellular region • specific granule lumen Prosesau biolegol • positive regulation of phagocytosis • small GTPase mediated signal transduction • alpha-beta T cell activation • GO:0019049, GO:0030683 mitigation of host defenses by virus • membrane raft polarization • negative thymic T cell selection • T cell proliferation • chemotaxis • alpha-beta T cell proliferation • macropinocytosis • cytoskeleton organization • myeloid dendritic cell activation involved in immune response • positive thymic T cell selection • establishment of T cell polarity • immunological synapse formation • actin cytoskeleton organization • T cell activation • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • neutrophil degranulation • regulation of molecular function Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1794	n/a
Ensembl	ENSG00000134516	n/a
UniProt	Q92608	n/a
RefSeq (mRNA)	NM_004946	n/a
RefSeq (protein)	NP_004937	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DOCK2 yw DOCK2 a elwir hefyd yn Dedicator of cytokinesis 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q35.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DOCK2.

• IMD40

Llyfryddiaeth

• "Investigation on cellular uptake and pharmacodynamics of DOCK2-inhibitory peptides conjugated with cell-penetrating peptides. ". Bioorg Med Chem. 2017. PMID 28284862.
• "Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections. ". N Engl J Med. 2015. PMID 26083206.
• "DOCK2 regulates cell proliferation through Rac and ERK activation in B cell lymphoma. ". Biochem Biophys Res Commun. 2010. PMID 20350533.
• "Immune regulatory functions of DOCK family proteins in health and disease. ". Exp Cell Res. 2013. PMID 23911989.
• "Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms.". Proc Natl Acad Sci U S A. 2012. PMID 22331897.