DNMT3A

DNMT3A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4U7T, 4QBR, 4U7P, 4QBS, 3A1B, 3LLR, 4QBQ, 3SVM, 3A1A, 2QRV
Dynodwyr
Cyfenwau	DNMT3A, DNMT3A2, M.HsaIIIA, TBRS, DNA (cytosine-5-)-methyltransferase 3 alpha, DNA methyltransferase 3 alpha, HESJAS
Dynodwyr allanol	OMIM: 602769 HomoloGene: 7294 GeneCards: DNMT3A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0102674, GO:0102675 methyltransferase activity • transferase activity • DNA binding • DNA-methyltransferase activity • chromatin binding • metal ion binding • GO:0001948, GO:0016582 protein binding • identical protein binding • DNA (cytosine-5-)-methyltransferase activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001106 transcription corepressor activity • transcription factor binding Cydrannau o'r gell • cytoplasm • GO:0035327 euchromatin • nuclear matrix • nucleoplasm • GO:0035328 heterochromatin • XY body • chromosome, centromeric region • cnewyllyn cell Prosesau biolegol • response to ionizing radiation • regulation of gene expression by genetic imprinting • C-5 methylation of cytosine • response to estradiol • positive regulation of cell death • cellular response to ethanol • GO:0010260 heneiddio • GO:1901227 negative regulation of transcription by RNA polymerase II • DNA methylation involved in gamete generation • response to vitamin A • DNA methylation • methylation • negative regulation of gene expression, epigenetic • response to nutrient levels • response to lead ion • DNA methylation-dependent heterochromatin assembly • spermatogenesis • neuron differentiation • GO:0007067 Mitosis • cellular response to amino acid stimulus • regulation of gene expression • DNA methylation involved in embryo development • response to ethanol • response to toxic substance • cellular response to hypoxia • hepatocyte apoptotic process • adwaith i gocên • DNA methylation on cytosine • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1788	n/a
Ensembl	ENSG00000119772	n/a
UniProt	Q9Y6K1	n/a
RefSeq (mRNA)	NM_022552 NM_153759 NM_175629 NM_175630 NM_001320892 NM_001320893 NM_001375819	n/a
RefSeq (protein)	NP_001307821 NP_001307822 NP_072046 NP_715640 NP_783328 NP_783329 NP_001362748	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DNMT3A yw DNMT3A a elwir hefyd yn DNA methyltransferase 3 alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2p23.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DNMT3A.

• TBRS
• DNMT3A2
• M.HsaIIIA

Llyfryddiaeth

• "Biologico-clinical significance of DNMT3A variants expression in acute myeloid leukemia. ". Biochem Biophys Res Commun. 2017. PMID 29024628.
• "DNMT3A mutations in Chinese childhood acute myeloid leukemia. ". Medicine (Baltimore). 2017. PMID 28767575.
• "Epigenetic Guardian: A Review of the DNA Methyltransferase DNMT3A in Acute Myeloid Leukaemia and Clonal Haematopoiesis. ". Biomed Res Int. 2017. PMID 28286768.
• "CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression. ". Cell. 2017. PMID 28215704.
• "Clinical implications of DNMT3Amutations in a Southeast Asian cohort of acute myeloid leukaemia patients.". J Clin Pathol. 2017. PMID 28100593.