DNAJA3

DNAJA3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2CTT, 2DN9
Dynodwyr
Cyfenwau	DNAJA3, HCA57, TID1, hTID-1, DnaJ heat shock protein family (Hsp40) member A3
Dynodwyr allanol	OMIM: 608382 HomoloGene: 36170 GeneCards: DNAJA3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • interferon-gamma receptor binding • heat shock protein binding • GO:0005083 GTPase regulator activity • unfolded protein binding • transcription factor binding • metal ion binding • NF-kappaB binding • GO:0001948, GO:0016582 protein binding • ATP binding • protein kinase binding • Hsp70 protein binding Cydrannau o'r gell • cytoplasm • cytosol • postsynaptic membrane • I-kappaB/NF-kappaB complex • intracellular membrane-bounded organelle • bilen • neuromuscular junction • Cellbilen • synapse • cell junction • mitochondrial matrix • mitocondria • Microffilament • extrinsic component of plasma membrane • mitochondrial nucleoid • IkappaB kinase complex • cnewyllyn cell Prosesau biolegol • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of interferon-gamma-mediated signaling pathway • T cell differentiation in thymus • response to interferon-gamma • negative regulation of protein kinase activity • small GTPase mediated signal transduction • protein stabilization • mitochondrion organization • negative regulation of apoptotic process • activation-induced cell death of T cells • response to heat • GO:1901227 negative regulation of transcription by RNA polymerase II • mitochondrial DNA replication • negative regulation of I-kappaB kinase/NF-kappaB signaling • protein folding • neuromuscular junction development • positive regulation of T cell proliferation • positive regulation of apoptotic process • negative regulation of programmed cell death • GO:0048552 regulation of catalytic activity • negative regulation of NF-kappaB transcription factor activity • activation of cysteine-type endopeptidase activity involved in apoptotic process • positive regulation of protein ubiquitination • negative regulation of cell population proliferation • GO:0097285 apoptotic process • skeletal muscle acetylcholine-gated channel clustering Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9093	n/a
Ensembl	ENSG00000276726 ENSG00000103423	n/a
UniProt	Q96EY1 Q53G26	n/a
RefSeq (mRNA)	NM_005147 NM_001135110 NM_001286516	n/a
RefSeq (protein)	NP_001128582 NP_001273445 NP_005138 NP_005138.3	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DNAJA3 yw DNAJA3 a elwir hefyd yn DnaJ heat shock protein family (Hsp40) member A3 a DnaJ (Hsp40) homolog, subfamily A, member 3 variant (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16p13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DNAJA3.

• TID1
• HCA57
• hTID-1

Llyfryddiaeth

• "Tid1 is a new regulator of p53 mitochondrial translocation and apoptosis in cancer. ". Oncogene. 2010. PMID 19935715.
• "Tid1 functions as a tumour suppressor in head and neck squamous cell carcinoma. ". J Pathol. 2009. PMID 19681071.
• "Essential role of TID1 in maintaining mitochondrial membrane potential homogeneity and mitochondrial DNA integrity. ". Mol Cell Biol. 2014. PMID 24492964.
• "Absence of a human DnaJ protein hTid-1S correlates with aberrant actin cytoskeleton organization in lesional psoriatic skin. ". J Biol Chem. 2012. PMID 22692211.
• "Direct interaction between p53 and Tid1 proteins affects p53 mitochondrial localization and apoptosis.". Oncotarget. 2010. PMID 21311096.