DMC1

DMC1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1V5W, 2ZJB, 4HYY
Dynodwyr
Cyfenwau	DMC1, DMC1H, LIM15, dJ199H16.1, DNA meiotic recombinase 1
Dynodwyr allanol	OMIM: 602721 HomoloGene: 5135 GeneCards: DMC1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • nucleotide binding • ATP-dependent activity, acting on DNA • DNA strand exchange activity • single-stranded DNA binding • GO:0001948, GO:0016582 protein binding • four-way junction DNA binding • double-stranded DNA binding • endodeoxyribonuclease activity • ATP binding Cydrannau o'r gell • Cromosom • nucleoplasm • telomere • cnewyllyn cell • condensed nuclear chromosome Prosesau biolegol • strand invasion • response to ionizing radiation • DNA recombinase assembly • female gamete generation • male meiosis I • DNA metabolic process • gamete generation • homologous chromosome pairing at meiosis • oocyte maturation • spermatogenesis • spermatid development • ovarian follicle development • cell cycle • GO:0051178 chromosome organization involved in meiotic cell cycle • mitotic recombination • GO:0100026 DNA repair • reciprocal meiotic recombination • GO:0007126 Meiosis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11144	n/a
Ensembl	ENSG00000100206	n/a
UniProt	Q14565	n/a
RefSeq (mRNA)	NM_001278208 NM_007068 NM_001363017	n/a
RefSeq (protein)	NP_001265137 NP_008999 NP_001349946	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DMC1 yw DMC1 a elwir hefyd yn DNA meiotic recombinase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 22, band 22q13.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DMC1.

• DMC1H
• LIM15
• dJ199H16.1

Llyfryddiaeth

• "Role of the conserved lysine within the Walker A motif of human DMC1. ". DNA Repair (Amst). 2013. PMID 23182424.
• "The resistance of DMC1 D-loops to dissociation may account for the DMC1 requirement in meiosis. ". Nat Struct Mol Biol. 2011. PMID 21151113.
• "Tolerance of DNA Mismatches in Dmc1 Recombinase-mediated DNA Strand Exchange. ". J Biol Chem. 2016. PMID 26709229.
• "Structure of a filament of stacked octamers of human DMC1 recombinase. ". Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013. PMID 23545642.
• "Mutations in DMC1 are not responsible for premature ovarian failure in Chinese women.". Reprod Biomed Online. 2013. PMID 23265958.