DLX2

DLX2
Dynodwyr
Cyfenwau	DLX2, TES-1, TES1, AW121999, Dlx-2, distal-less homeobox 2
Dynodwyr allanol	OMIM: 126255 HomoloGene: 3244 GeneCards: DLX2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • chromatin binding • GO:0001948, GO:0016582 protein binding • single-stranded RNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding Cydrannau o'r gell • cnewyllyn cell Prosesau biolegol • cerebral cortex GABAergic interneuron differentiation • proximal/distal pattern formation • cell differentiation • GO:0009373 regulation of transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • branching morphogenesis of a nerve • embryonic skeletal system development • multicellular organism development • odontogenesis of dentin-containing tooth • cerebral cortex GABAergic interneuron fate commitment • cartilage development • brain development • negative regulation of oligodendrocyte differentiation • forebrain neuron differentiation • embryonic cranial skeleton morphogenesis • olfactory bulb development • hippocampus development • subpallium development • negative regulation of Notch signaling pathway • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of cell differentiation • negative regulation of photoreceptor cell differentiation • positive regulation of amacrine cell differentiation • transcription, DNA-templated Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1746	n/a
Ensembl	ENSG00000115844	n/a
UniProt	Q07687	n/a
RefSeq (mRNA)	NM_004405	n/a
RefSeq (protein)	NP_004396 NP_004396.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DLX2 yw DLX2 a elwir hefyd yn Distal-less homeobox 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q31.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DLX2.

• TES1
• TES-1

Llyfryddiaeth

• "Overexpression of DLX2 is associated with poor prognosis and sorafenib resistance in hepatocellular carcinoma. ". Exp Mol Pathol. 2016. PMID 27302463.
• "A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling. ". Genes Dev. 2016. PMID 26833729.
• "Smad2/3-Regulated Expression of DLX2 Is Associated with Radiation-Induced Epithelial-Mesenchymal Transition and Radioresistance of A549 and MDA-MB-231 Human Cancer Cell Lines. ". PLoS One. 2016. PMID 26799321.
• "Dlx-2 is implicated in TGF-β- and Wnt-induced epithelial-mesenchymal, glycolytic switch, and mitochondrial repression by Snail activation. ". Int J Oncol. 2015. PMID 25651912.
• "Increased expression of DLX2 correlates with advanced stage of gastric adenocarcinoma.". World J Gastroenterol. 2013. PMID 23674878.