DLG4

DLG4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1KEF, 3I4W, 3K82, 3ZRT
Dynodwyr
Cyfenwau	DLG4, PSD95, SAP-90, SAP90, Dlgh4, PSD-95, SAP90A, discs large homolog 4, discs large MAGUK scaffold protein 4, MRD62
Dynodwyr allanol	OMIM: 602887 HomoloGene: 1047 GeneCards: DLG4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • beta-1 adrenergic receptor binding • PDZ domain binding • GO:0032403 protein-containing complex binding • scaffold protein binding • guanylate kinase activity • P2Y1 nucleotide receptor binding • acetylcholine receptor binding • kinase binding • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • ionotropic glutamate receptor binding • D1 dopamine receptor binding • protein phosphatase binding • neuroligin family protein binding • ligand-gated ion channel activity Cydrannau o'r gell • cytoplasm • juxtaparanode region of axon • endocytic vesicle membrane • synaptic membrane • postsynaptic membrane • cell projection • bilen • GO:0097483, GO:0097481 postsynaptic density • synaptic vesicle • extrinsic component of cytoplasmic side of plasma membrane • voltage-gated potassium channel complex • cortical cytoskeleton • Cellbilen • dendritic spine • synapse • excitatory synapse • cerebellar mossy fiber • axon • cell junction • dendrite • basolateral plasma membrane • Reticwlwm endoplasmig • neuron spine • AMPA glutamate receptor complex • dendrite cytoplasm • ionotropic glutamate receptor complex • neuron projection terminus • cyrion cell • cytosol • postsynaptic density membrane • postsynapse • neuromuscular junction • neuron projection • glutamatergic synapse Prosesau biolegol • receptor localization to synapse • regulation of grooming behavior • regulation of long-term neuronal synaptic plasticity • neuromuscular process controlling balance • negative regulation of receptor internalization • establishment of protein localization • positive regulation of cytosolic calcium ion concentration • learning • nervous system development • MAPK cascade • locomotory exploration behavior • regulation of NMDA receptor activity • AMPA glutamate receptor clustering • dendritic spine morphogenesis • vocalization behavior • positive regulation of synaptic transmission • establishment or maintenance of epithelial cell apical/basal polarity • positive regulation of excitatory postsynaptic potential • social behavior • synaptic vesicle maturation • protein localization to synapse • GO:0072468 signal transduction • GMP metabolic process • GDP metabolic process • chemical synaptic transmission • transmembrane transport • cellular response to potassium ion • receptor clustering • positive regulation of protein tyrosine kinase activity • GO:0034622 protein-containing complex assembly • cell-cell adhesion • postsynaptic neurotransmitter receptor diffusion trapping • positive regulation of neuron projection arborization • neurotransmitter receptor localization to postsynaptic specialization membrane Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1742	n/a
Ensembl	ENSG00000132535	n/a
UniProt	P78352 O14909	n/a
RefSeq (mRNA)	NM_001128827 NM_001365 NM_001321074 NM_001321075 NM_001321076 NM_001321077 NM_001369566	n/a
RefSeq (protein)	NP_001122299 NP_001308003 NP_001308004 NP_001308005 NP_001308006 NP_001356	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DLG4 yw DLG4 a elwir hefyd yn Discs, large homolog 4 (Drosophila), isoform CRA_d (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17p13.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DLG4.

• PSD95
• SAP90
• SAP-90

Llyfryddiaeth

• "Site-Specific Phosphorylation of PSD-95 PDZ Domains Reveals Fine-Tuned Regulation of Protein-Protein Interactions. ". ACS Chem Biol. 2017. PMID 28692247.
• "Association analysis of genetic variant of rs13331 in PSD95 gene with autism spectrum disorders: A case-control study in a Chinese population. ". J Huazhong Univ Sci Technolog Med Sci. 2016. PMID 27072977.
• "Postsynaptic nanodomains generated by local palmitoylation cycles. ". Biochem Soc Trans. 2015. PMID 25849917.
• "Targeting protein-protein interactions with trimeric ligands: high affinity inhibitors of the MAGUK protein family. ". PLoS One. 2015. PMID 25658767.
• "Population-specific haplotype association of the postsynaptic density gene DLG4 with schizophrenia, in family-based association studies.". PLoS One. 2013. PMID 23936182.