DLG3

DLG3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1UM7, 2FE5, 2I1N
Dynodwyr
Cyfenwau	DLG3, MRX, MRX90, NEDLG, PPP1R82, SAP102, XLMR, discs large homolog 3, discs large MAGUK scaffold protein 3, XLID90
Dynodwyr allanol	OMIM: 300189 HomoloGene: 41157 GeneCards: DLG3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phosphatase binding • PDZ domain binding • protein domain specific binding • guanylate kinase activity • kinase binding • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • ionotropic glutamate receptor binding • protein phosphatase binding • ubiquitin protein ligase binding • ligand-gated ion channel activity • structural constituent of postsynaptic density Cydrannau o'r gell • cytoplasm • postsynaptic membrane • GO:0097483, GO:0097481 postsynaptic density • cell-cell junction • bicellular tight junction • growth cone • Cellbilen • synapse • dendritic shaft • neuronal cell body • basolateral plasma membrane • AMPA glutamate receptor complex • ionotropic glutamate receptor complex • extracellular space • cytosol • cell junction • neuromuscular junction • neuron projection • postsynaptic density membrane • glutamatergic synapse • postsynaptic density, intracellular component Prosesau biolegol • receptor localization to synapse • negative regulation of phosphatase activity • establishment of planar polarity • receptor clustering • nervous system development • establishment or maintenance of epithelial cell apical/basal polarity • negative regulation of cell population proliferation • cludo transmembrane rhwng ïonau • GMP metabolic process • GDP metabolic process • chemical synaptic transmission • MAPK cascade • positive regulation of protein tyrosine kinase activity • cell-cell adhesion • regulation of postsynaptic membrane neurotransmitter receptor levels • maintenance of postsynaptic density structure • regulation of NMDA receptor activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1741	n/a
Ensembl	ENSG00000082458	n/a
UniProt	Q92796	n/a
RefSeq (mRNA)	NM_001166278 NM_020730 NM_021120	n/a
RefSeq (protein)	NP_001159750 NP_065781 NP_066943	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DLG3 yw DLG3 a elwir hefyd yn Discs large MAGUK scaffold protein 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xq13.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DLG3.

• MRX
• XLMR
• MRX90
• NEDLG
• SAP102
• PPP1R82

Llyfryddiaeth

• "Skewed X-inactivation in a family with DLG3-associated X-linked intellectual disability. ". Am J Med Genet A. 2017. PMID 28777483.
• "A non-coding variant in the 5' UTR of DLG3 attenuates protein translation to cause non-syndromic intellectual disability. ". Eur J Hum Genet. 2016. PMID 27222290.
• "Gene expression profiling analysis reveals that DLG3 is down-regulated in glioblastoma. ". J Neurooncol. 2014. PMID 24381070.
• "Polymorphisms in the DLG3 gene is not associated with non-syndromic mental retardation in the Chinese Han population of Qin-Ba mountain. ". Cell Mol Neurobiol. 2011. PMID 21369957.
• "A novel mutation in the DLG3 gene encoding the synapse-associated protein 102 (SAP102) causes non-syndromic mental retardation.". Neurogenetics. 2010. PMID 19795139.