DLG1

DLG1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1PDR, 2M3M, 2OQS, 2X7Z, 3RL7, 3RL8, 3W9Y, 4AMH, 4G69
Dynodwyr
Cyfenwau	DLG1, DLGH1, SAP-97, SAP97, dJ1061C18.1.1, hdlg, B130052P05Rik, E-dlg/SAP97, mKIAA4187, discs large homolog 1, scribble cell polarity complex component, discs large MAGUK scaffold protein 1
Dynodwyr allanol	OMIM: 601014 HomoloGene: 20869 GeneCards: DLG1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • phosphatase binding • phosphoprotein phosphatase activity • transmembrane transporter binding • cytoskeletal protein binding • protein C-terminus binding • ionotropic glutamate receptor binding • kinase binding • mitogen-activated protein kinase kinase binding • guanylate kinase activity • GO:0001948, GO:0016582 protein binding • GO:0032947 molecular adaptor activity • protein kinase binding • L27 domain binding • ligand-gated ion channel activity • potassium channel regulator activity • cadherin binding • structural constituent of postsynaptic density Cydrannau o'r gell • cytoplasm • cytosol • postsynaptic membrane • bilen • cell-cell junction • bicellular tight junction • node of Ranvier • synapse • perinuclear region of cytoplasm • cytoplasmic side of plasma membrane • microtubule • cnewyllyn cell • cell projection membrane • membrane raft • ionotropic glutamate receptor complex • extracellular exosome • Golgi apparatus • lateral plasma membrane • intercalated disc • neuromuscular junction • myelin sheath abaxonal region • lateral loop • endoplasmic reticulum membrane • MPP7-DLG1-LIN7 complex • sarcolemma • GO:0097483, GO:0097481 postsynaptic density • cell junction • basolateral plasma membrane • Cellbilen • Reticwlwm endoplasmig • immunological synapse • basement membrane • apical plasma membrane • neuron projection • postsynaptic density membrane • glutamatergic synapse Prosesau biolegol • embryonic skeletal system morphogenesis • ureteric bud development • positive regulation of actin filament polymerization • positive regulation of potassium ion transport • negative regulation of p38MAPK cascade • amyloid precursor protein metabolic process • tissue morphogenesis • reproductive structure development • membrane raft organization • hard palate development • endothelial cell proliferation • smooth muscle tissue development • negative regulation of epithelial cell proliferation • regulation of sodium ion transmembrane transport • astral microtubule organization • actin filament organization • mitotic cell cycle checkpoint signaling • receptor clustering • establishment or maintenance of cell polarity • negative regulation of T cell proliferation • branching involved in ureteric bud morphogenesis • regulation of myelination • cortical microtubule organization • establishment or maintenance of epithelial cell apical/basal polarity • GO:0022415 viral process • T cell cytokine production • T cell activation • peristalsis • receptor localization to synapse • negative regulation of protein kinase B signaling • regulation of NIK/NF-kappaB signaling • GO:1901227 negative regulation of transcription by RNA polymerase II • nervous system development • regulation of cell shape • establishment of centrosome localization • immunological synapse formation • GO:0033109 cortical actin cytoskeleton organization • GO:0034613 protein localization • lens development in camera-type eye • bicellular tight junction assembly • positive regulation of cell population proliferation • negative regulation of ERK1 and ERK2 cascade • activation of protein kinase activity • negative regulation of mitotic cell cycle • regulation of membrane potential • protein localization to plasma membrane • GDP metabolic process • cludo transmembrane rhwng ïonau • GO:0016576 protein dephosphorylation • GMP metabolic process • chemical synaptic transmission • regulation of ventricular cardiac muscle cell action potential • regulation of potassium ion import • regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization • regulation of potassium ion export across plasma membrane • MAPK cascade • cell-cell adhesion • maintenance of postsynaptic density structure • neurotransmitter receptor localization to postsynaptic specialization membrane • positive regulation of protein localization to plasma membrane • regulation of NMDA receptor activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1739	n/a
Ensembl	ENSG00000075711	n/a
UniProt	Q12959	n/a
RefSeq (mRNA)	NM_001098424 NM_001204386 NM_001204387 NM_001204388 NM_001290983 NM_004087 NM_001363865 NM_001366203 NM_001366204 NM_001366205 NM_001366206 NM_001366207 NM_001366208 NM_001366209 NM_001366210 NM_001366211 NM_001366212 NM_001366213 NM_001366214 NM_001366215 NM_001366216 NM_001366217 NM_001366218 NM_001366219 NM_001366220 NM_001366221 NM_001366222	n/a
RefSeq (protein)	NP_001091894 NP_001191315 NP_001191316 NP_001191317 NP_001277912 NP_004078 NP_001350794 NP_001353132 NP_001353133 NP_001353134 NP_001353135 NP_001353136 NP_001353137 NP_001353138 NP_001353139 NP_001353140 NP_001353141 NP_001353142 NP_001353143 NP_001353144 NP_001353145 NP_001353146 NP_001353147 NP_001353148 NP_001353149 NP_001353150 NP_001353151	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DLG1 yw DLG1 a elwir hefyd yn Disks large homolog 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3q29.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DLG1.

• hdlg
• DLGH1
• SAP97
• SAP-97
• dJ1061C18.1.1

Llyfryddiaeth

• "DLG1 polarity protein expression associates with the disease progress of low-grade cervical intraepithelial lesions. ". Exp Mol Pathol. 2017. PMID 28040505.
• "Disc large 1 expression is altered by human papillomavirus E6/E7 proteins in organotypic cultures of human keratinocytes. ". J Gen Virol. 2016. PMID 26653181.
• "Reduced cortical expression of a newly identified splicing variant of the DLG1 gene in patients with early-onset schizophrenia. ". Transl Psychiatry. 2015. PMID 26440542.
• "Transcriptional and translational mechanisms contribute to regulate the expression of Discs Large 1 protein during different biological processes. ". Biol Chem. 2015. PMID 25720117.
• "SAP97 blocks the RXR ER retention signal of NMDA receptor subunit GluN1-3 through its SH3 domain.". Biochim Biophys Acta. 2015. PMID 25499266.