DIABLO

DIABLO
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1FEW, 1G3F, 1G73, 1OXQ, 1TW6, 1XB0, 1XB1, 3D9U, 3UIH, 3UIJ, 4TX5
Dynodwyr
Cyfenwau	DIABLO, DFNA64, SMAC, Diablo, Diablo homolog, diablo IAP-binding mitochondrial protein
Dynodwyr allanol	OMIM: 605219 HomoloGene: 10532 GeneCards: DIABLO
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytosol • mitochondrial intermembrane space • mitocondria • cytoplasmic side of plasma membrane • CD40 receptor complex Prosesau biolegol • intrinsic apoptotic signaling pathway • activation of cysteine-type endopeptidase activity involved in apoptotic process • extrinsic apoptotic signaling pathway via death domain receptors • GO:0097285 apoptotic process • activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c • positive regulation of apoptotic process • intrinsic apoptotic signaling pathway in response to oxidative stress • neuron apoptotic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	56616	n/a
Ensembl	ENSG00000184047	n/a
UniProt	Q9NR28	n/a
RefSeq (mRNA)	NM_138930 NM_001278302 NM_001278303 NM_001278304 NM_001278342 NM_019887 NM_138929 NM_001371333	n/a
RefSeq (protein)	NP_001265231 NP_001265232 NP_001265233 NP_001265271 NP_063940 NP_620308 NP_001358262 NP_001265231.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DIABLO yw DIABLO a elwir hefyd yn Diablo homolog, mitochondrial a SMAC-epsilon (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q24.31.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DIABLO.

• SMAC
• DFNA64

Llyfryddiaeth

• "Promises and Challenges of Smac Mimetics as Cancer Therapeutics. ". Clin Cancer Res. 2015. PMID 26567362.
• "The activator of apoptosis Smac-DIABLO acts as a tetramer in solution. ". Biophys J. 2015. PMID 25650938.
• "Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms. ". Nat Commun. 2017. PMID 28839138.
• "Downregulation of Smac attenuates H2O2-induced apoptosis via endoplasmic reticulum stress in human lens epithelial cells. ". Medicine (Baltimore). 2017. PMID 28682901.
• "A novel Smac mimetic APG-1387 demonstrates potent antitumor activity in nasopharyngeal carcinoma cells by inducing apoptosis.". Cancer Lett. 2016. PMID 27424523.