DHX58

DHX58
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2RQA, 2W4R, 3EQT
Dynodwyr
Cyfenwau	DHX58, D11LGP2, D11lgp2e, LGP2, RLR-3, DEXH-box helicase 58
Dynodwyr allanol	OMIM: 608588 HomoloGene: 69371 GeneCards: DHX58
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • nucleotide binding • GO:0008026 helicase activity • zinc ion binding • metal ion binding • GO:0001948, GO:0016582 protein binding • single-stranded RNA binding • RNA binding • double-stranded RNA binding • hydrolase activity • ATP binding Cydrannau o'r gell • cytoplasm Prosesau biolegol • negative regulation of MDA-5 signaling pathway • regulation of innate immune response • immune system process • response to virus • positive regulation of RIG-I signaling pathway • defense response to virus • negative regulation of innate immune response • negative regulation of type I interferon production • innate immune response • GO:0022415 viral process • positive regulation of MDA-5 signaling pathway • positive regulation of type I interferon production • negative regulation of RIG-I signaling pathway • response to bacterium Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	79132	n/a
Ensembl	ENSG00000108771	n/a
UniProt	Q96C10	n/a
RefSeq (mRNA)	NM_024119	n/a
RefSeq (protein)	NP_077024	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DHX58 yw DHX58 a elwir hefyd yn Probable ATP-dependent RNA helicase DHX58 a DExH-box helicase 58 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q21.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DHX58.

• LGP2
• RLR-3
• D11LGP2
• D11lgp2e

Llyfryddiaeth

• "The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly. ". Mol Cell. 2014. PMID 25127512.
• "LGP2 downregulates interferon production during infection with seasonal human influenza A viruses that activate interferon regulatory factor 3. ". J Virol. 2012. PMID 22837208.
• "ATP hydrolysis enhances RNA recognition and antiviral signal transduction by the innate immune sensor, laboratory of genetics and physiology 2 (LGP2). ". J Biol Chem. 2013. PMID 23184951.
• "Laboratory of genetics and physiology 2 (LGP2) plays an essential role in hepatitis C virus infection-induced interferon responses. ". Hepatology. 2017. PMID 28090671.
• "LGP2 synergy with MDA5 in RLR-mediated RNA recognition and antiviral signaling.". Cytokine. 2015. PMID 25794939.