DHH

DHH
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2WFQ, 2WFR, 2WG3, 3N1G, 3N1Q
Dynodwyr
Cyfenwau	DHH, GDXYM, HHG-3, SRXY7, C78960, desert hedgehog, desert hedgehog signaling molecule, GDMN
Dynodwyr allanol	OMIM: 605423 HomoloGene: 22431 GeneCards: DHH
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • zinc ion binding • metal ion binding • patched binding • GO:0070122 peptidase activity • GO:0001948, GO:0016582 protein binding • hydrolase activity Cydrannau o'r gell • bilen • Cellbilen • extracellular region • extracellular space Prosesau biolegol • response to estradiol • Leydig cell differentiation • cell-cell signaling • regulation of steroid biosynthetic process • male sex determination • proteolysis • response to estrogen • multicellular organism development • spermatid development • myelination • osteoblast differentiation • smoothened signaling pathway • cell fate specification • regulation of gene expression Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	50846	n/a
Ensembl	ENSG00000139549	n/a
UniProt	O43323	n/a
RefSeq (mRNA)	NM_021044	n/a
RefSeq (protein)	NP_066382	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DHH yw DHH a elwir hefyd yn Desert hedgehog (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q13.12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DHH.

• GDXYM
• HHG-3
• SRXY7

Llyfryddiaeth

• "46,XY Gonadal Dysgenesis due to a Homozygous Mutation in Desert Hedgehog (DHH) Identified by Exome Sequencing. ". J Clin Endocrinol Metab. 2015. PMID 25927242.
• "In vitro and molecular modeling analysis of two mutant desert hedgehog proteins associated with 46,XY gonadal dysgenesis. ". DNA Cell Biol. 2013. PMID 23786321.
• "Novel homozygous mutations in Desert hedgehog gene in patients with 46,XY complete gonadal dysgenesis and prediction of its structural and functional implications by computational methods. ". Eur J Med Genet. 2011. PMID 21816240.
• "Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways. ". Cell Cycle. 2010. PMID 20081366.
• "A heterozygous mutation in the desert hedgehog gene in patients with mixed gonadal dysgenesis.". Mol Hum Reprod. 2005. PMID 16390857.