DGCR8

DGCR8
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1X47, 2YT4, 3LE4, 5B16
Dynodwyr
Cyfenwau	DGCR8, C22orf12, DGCRK6, Gy1, pasha, Pasha, DGCR8 microprocessor complex subunit, microprocessor complex subunit
Dynodwyr allanol	OMIM: 609030 HomoloGene: 11223 GeneCards: DGCR8
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • primary miRNA binding • ribonuclease III activity • double-stranded RNA binding • GO:0001948, GO:0016582 protein binding • heme binding • protein homodimerization activity • metal ion binding • RNA binding • identical protein binding Cydrannau o'r gell • cytoplasm • microprocessor complex • nucleolus • cnewyllyn cell • nucleoplasm • GO:0097483, GO:0097481 postsynaptic density Prosesau biolegol • regulation of stem cell proliferation • GO:1990744, GO:1990729 primary miRNA processing • RNA phosphodiester bond hydrolysis, endonucleolytic • RNA phosphodiester bond hydrolysis • GO:0061715 miRNA metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	54487	n/a
Ensembl	ENSG00000128191	n/a
UniProt	Q8WYQ5	n/a
RefSeq (mRNA)	NM_001190326 NM_022720	n/a
RefSeq (protein)	NP_001177255 NP_073557	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DGCR8 yw DGCR8 a elwir hefyd yn DGCR8, microprocessor complex subunit (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 22, band 22q11.21.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DGCR8.

• Gy1
• pasha
• DGCRK6
• C22orf12

Llyfryddiaeth

• "Upregulation of the double-stranded RNA binding protein DGCR8 in invasive ductal breast carcinoma. ". Gene. 2016. PMID 26804549.
• "Silencing the double-stranded RNA binding protein DGCR8 inhibits ovarian cancer cell proliferation, migration, and invasion. ". Pharm Res. 2015. PMID 25823356.
• "DGCR8 Mediates Repair of UV-Induced DNA Damage Independently of RNA Processing. ". Cell Rep. 2017. PMID 28380355.
• "CO and NO bind to Fe(II) DiGeorge critical region 8 heme but do not restore primary microRNA processing activity. ". J Biol Inorg Chem. 2016. PMID 27766492.
• "Analysis of Heme Iron Coordination in DGCR8: The Heme-Binding Component of the Microprocessor Complex.". Biochemistry. 2016. PMID 27546061.