DFFB

DFFB
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1IBX
Dynodwyr
Cyfenwau	DFFB, DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase), CAD, CPAN, DFF-40, DFF2, DFF40, DNA fragmentation factor subunit beta
Dynodwyr allanol	OMIM: 601883 HomoloGene: 3241 GeneCards: DFFB
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • enzyme binding • nuclease activity • hydrolase activity • GO:0001948, GO:0016582 protein binding • deoxyribonuclease activity • protein domain specific binding • identical protein binding • disordered domain specific binding Cydrannau o'r gell • cytoplasm • cytosol • nucleolus • intracellular anatomical structure • cnewyllyn cell • nucleoplasm Prosesau biolegol • apoptotic DNA fragmentation • apoptotic chromosome condensation • GO:0097285 apoptotic process • DNA catabolic process • protein homooligomerization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1677	n/a
Ensembl	ENSG00000169598	n/a
UniProt	O76075	n/a
RefSeq (mRNA)	NM_001004285 NM_001004286 NM_001282669 NM_004402 NM_001320132 NM_001320136	n/a
RefSeq (protein)	NP_001269598 NP_001307061 NP_001307065 NP_004393	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DFFB yw DFFB a elwir hefyd yn DNA fragmentation factor subunit beta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p36.32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DFFB.

• CAD
• CPAN
• DFF2
• DFF40
• DFF-40

Llyfryddiaeth

• "An intrinsic DFF40/CAD endonuclease deficiency impairs oligonucleosomal DNA hydrolysis during caspase-dependent cell death: a common trait in human glioblastoma cells. ". Neuro Oncol. 2016. PMID 26755073.
• "Sensitization of breast cancer cells to doxorubicin via stable cell line generation and overexpression of DFF40. ". Biochem Cell Biol. 2015. PMID 26529233.
• "Stable overexpression of DNA fragmentation factor in T-47D cells: sensitization of breast cancer cells to apoptosis in response to acetazolamide and sulfabenzamide. ". Mol Biol Rep. 2014. PMID 25086620.
• "Caspase-activated DNase is necessary and sufficient for oligonucleosomal DNA breakdown, but not for chromatin disassembly during caspase-dependent apoptosis of LN-18 glioblastoma cells. ". J Biol Chem. 2014. PMID 24838313.
• "Septic sera induces apoptosis and DNA fragmentation factor 40 activation in fibroblasts.". Biochem Biophys Res Commun. 2011. PMID 21820410.