DFFA

DFFA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1IBX, 1IYR, 1KOY
Dynodwyr
Cyfenwau	DFFA, DFF-45, DFF1, ICAD, DNA fragmentation factor subunit alpha
Dynodwyr allanol	OMIM: 601882 HomoloGene: 3240 GeneCards: DFFA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • protein domain specific binding • protein folding chaperone activity • deoxyribonuclease inhibitor activity Cydrannau o'r gell • cytosol • lipid droplet • intracellular anatomical structure • cnewyllyn cell • nucleoplasm • cytoplasm • Cellbilen Prosesau biolegol • positive regulation of apoptotic process • negative regulation of execution phase of apoptosis • negative regulation of apoptotic DNA fragmentation • apoptotic DNA fragmentation • thymocyte apoptotic process • GO:0097285 apoptotic process • negative regulation of deoxyribonuclease activity • chaperone-mediated protein folding Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1676	n/a
Ensembl	ENSG00000160049	n/a
UniProt	O00273	n/a
RefSeq (mRNA)	NM_213566 NM_004401	n/a
RefSeq (protein)	NP_004392 NP_998731 NP_998731.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DFFA yw DFFA a elwir hefyd yn DNAation factor, 45kDa, alpha polypeptide, isoform CRA_b a DNA fragmentation factor subunit alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p36.22.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DFFA.

• DFF1
• ICAD
• DFF-45

Llyfryddiaeth

• "siRNA-mediated knock-down of DFF45 amplifies doxorubicin therapeutic effects in breast cancer cells. ". Cell Oncol (Dordr). 2013. PMID 24277473.
• "DFF45 expression in human endometrium is associated with menstrual cycle phases and decreases after menopause. ". Gynecol Obstet Invest. 2012. PMID 22378161.
• "DFF45 expression in ovarian endometriomas. ". Eur J Obstet Gynecol Reprod Biol. 2009. PMID 19535198.
• "Identification and characterization of the human inhibitor of caspase-activated DNase gene promoter. ". Apoptosis. 2008. PMID 18500556.
• "Antiapoptotic regulation by hepatitis C virus core protein through up-regulation of inhibitor of caspase-activated DNase.". Virology. 2003. PMID 14675622.