DDX41

DDX41
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2P6N, 5GVR, 5H1Y, 5GVS, 8C6J
Dynodwyr
Cyfenwau	DDX41, ABS, MPLPF, DEAD-box helicase 41
Dynodwyr allanol	OMIM: 608170 HomoloGene: 9431 GeneCards: DDX41
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • nucleotide binding • GO:0008026 helicase activity • metal ion binding • GO:0001948, GO:0016582 protein binding • nucleic acid binding • hydrolase activity • ATP binding • RNA binding Cydrannau o'r gell • cytosol • catalytic step 2 spliceosome • bilen • Reticwlwm endoplasmig • cnewyllyn cell • spliceosomal complex • nucleolus • cytoplasm Prosesau biolegol • cellular response to interferon-beta • mRNA processing • regulation of type I interferon production • defense response to virus • RNA secondary structure unwinding • RNA splicing • positive regulation of type I interferon production • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0097285 apoptotic process • mRNA splicing, via spliceosome • cell population proliferation • cell differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	51428	n/a
Ensembl	ENSG00000183258	n/a
UniProt	Q9UJV9	n/a
RefSeq (mRNA)	NM_016222 NM_001321732 NM_001321830	n/a
RefSeq (protein)	NP_001308661 NP_001308759 NP_057306	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DDX41 yw DDX41 a elwir hefyd yn Probable ATP-dependent RNA helicase DDX41 a DEAD-box helicase 41 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q35.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DDX41.

• ABS
• MPLPF

Llyfryddiaeth

• "The DEAD-box RNA helicase DDX41 is a novel repressor of p21WAF1/CIP1 mRNA translation. ". J Biol Chem. 2017. PMID 28348086.
• "Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid malignancies. ". Blood. 2016. PMID 26712909.
• "Myeloid neoplasms with germline DDX41 mutation. ". Int J Hematol. 2017. PMID 28547672.
• "The emerging roles of the DDX41 protein in immunity and diseases. ". Protein Cell. 2017. PMID 27502187.
• "Biological implications of somatic DDX41 p.R525H mutation in acute myeloid leukemia.". Exp Hematol. 2016. PMID 27174803.