DAPK3

DAPK3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1YRP, 2J90, 3BHY, 3BQR, 5A6O, 5A6N
Dynodwyr
Cyfenwau	DAPK3, DLK, ZIP, ZIPK, death-associated protein kinase 3, death associated protein kinase 3
Dynodwyr allanol	OMIM: 603289 HomoloGene: 20353 GeneCards: DAPK3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • protein homodimerization activity • cAMP response element binding protein binding • kinase activity • protein serine/threonine kinase activity • leucine zipper domain binding • GO:0001948, GO:0016582 protein binding • identical protein binding • ATP binding • protein C-terminus binding Cydrannau o'r gell • PML body • Microffilament • membrane raft • cnewyllyn cell • cytoplasm Prosesau biolegol • regulation of apoptotic process • regulation of actin cytoskeleton reorganization • negative regulation of translation • GO:0007243 intracellular signal transduction • GO:0009373 regulation of transcription, DNA-templated • regulation of smooth muscle contraction • phosphorylation • positive regulation of cell migration • positive regulation of canonical Wnt signaling pathway • regulation of myosin II filament organization • transcription, DNA-templated • regulation of cell motility • protein phosphorylation • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand • regulation of autophagy • neuron differentiation • regulation of mitotic cell cycle • regulation of cell shape • positive regulation of apoptotic process • regulation of focal adhesion assembly • cellular response to interferon-gamma • apoptotic signaling pathway • protein autophosphorylation • regulation of translation • regulation of mitotic nuclear division • GO:0097285 apoptotic process • GO:0035404 peptidyl-serine phosphorylation • peptidyl-threonine phosphorylation • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1613	n/a
Ensembl	ENSG00000167657	n/a
UniProt	O43293	n/a
RefSeq (mRNA)	NM_001348 NM_001375658	n/a
RefSeq (protein)	NP_001339 NP_001362587	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DAPK3 yw DAPK3 a elwir hefyd yn Death associated protein kinase 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19p13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DAPK3.

• DLK
• ZIP
• ZIPK

Llyfryddiaeth

• "Activation of AKT negatively regulates the pro-apoptotic function of death-associated protein kinase 3 (DAPK3) in prostate cancer. ". Cancer Lett. 2016. PMID 27126362.
• "Biophysical changes of ATP binding pocket may explain loss of kinase activity in mutant DAPK3 in cancer: A molecular dynamic simulation analysis. ". Gene. 2016. PMID 26748242.
• "Phosphorylation of myosin II regulatory light chain by ZIP kinase is responsible for cleavage furrow ingression during cell division in mammalian cultured cells. ". Biochem Biophys Res Commun. 2015. PMID 25769953.
• "ZIPK is critical for the motility and contractility of VSMCs through the regulation of nonmuscle myosin II isoforms. ". Am J Physiol Heart Circ Physiol. 2014. PMID 24633547.
• "Link of Dlk/ZIP kinase to cell apoptosis and tumor suppression.". Biochem Biophys Res Commun. 2010. PMID 20085750.