DAG1

DAG1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1EG4, 2MK7
Dynodwyr
Cyfenwau	DAG1, 156DAG, A3a, AGRNR, DAG, MDDGC7, MDDGC9, MDDGA9, dystroglycan 1, LGMDR16
Dynodwyr allanol	OMIM: 128239 HomoloGene: 3234 GeneCards: DAG1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• calcium ion binding; • GO:0001948, GO:0016582 protein binding; • virus receptor activity; • alpha-actinin binding; • vinculin binding; • actin binding; • tubulin binding; • structural constituent of muscle; • SH2 domain binding; • laminin binding; • laminin-1 binding; • dystroglycan binding;
Cydrannau o'r gell	• cell-cell junction; • cnewyllyn cell; • synapse; • contractile ring; • filopodium; • node of Ranvier; • costamere; • lamellipodium; • dystroglycan complex; • membrane raft; • cell junction; • Cytosgerbwd; • bilen; • extracellular exosome; • basolateral plasma membrane; • postsynaptic membrane; • sarcolemma; • cytoplasm; • integral component of membrane; • focal adhesion; • Cellbilen; • dystrophin-associated glycoprotein complex; • nucleoplasm; • basement membrane; • cytosol; • extracellular space; • endoplasmic reticulum lumen; • Golgi lumen; • plasma membrane raft; • external side of plasma membrane; • nuclear periphery; • GO:0005578 extracellular matrix; • extracellular region; • collagen-containing extracellular matrix; • glutamatergic synapse; • GABA-ergic synapse; • postsynaptic cytosol;
Prosesau biolegol	• NLS-bearing protein import into nucleus; • extracellular matrix organization; • GO:0022415 viral process; • regulation of embryonic cell shape; • response to peptide hormone; • regulation of epithelial to mesenchymal transition; • positive regulation of basement membrane assembly involved in embryonic body morphogenesis; • viral entry into host cell; • regulation of gastrulation; • negative regulation of cell migration; • Schwann cell development; • membrane protein ectodomain proteolysis; • calcium-dependent cell-matrix adhesion; • negative regulation of MAPK cascade; • nerve maturation; • microtubule anchoring; • commissural neuron axon guidance; • branching involved in salivary gland morphogenesis; • negative regulation of protein kinase B signaling; • morphogenesis of an epithelial sheet; • myelination in peripheral nervous system; • basement membrane organization; • epithelial tube branching involved in lung morphogenesis; • modulation by virus of host process; • protein O-linked glycosylation; • positive regulation of cell-matrix adhesion; • GO:0010260 heneiddio; • Schwann cell differentiation; • response to denervation involved in regulation of muscle adaptation; • nerve development; • axon regeneration; • positive regulation of myelination; • skeletal muscle tissue regeneration; • positive regulation of protein kinase activity; • positive regulation of oligodendrocyte differentiation; • cellular response to mechanical stimulus; • cellular response to cholesterol; • angiogenesis involved in wound healing; • GO:1904739 regulation of synapse organization; • regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; • retrograde trans-synaptic signaling by trans-synaptic protein complex;
	Sources:Amigo / QuickGO
Orthologau
	1605
	n/a
	ENSG00000173402
	n/a
	Q14118
	n/a
NM_004393; NM_001165928; NM_001177634; NM_001177635; NM_001177636;
	NM_001177637; NM_001177638; NM_001177639; NM_001177640; NM_001177641; NM_001177642; NM_001177643; NM_001177644
	n/a
NP_001159400; NP_001171105; NP_001171106; NP_001171107; NP_001171108;
	NP_001171109; NP_001171110; NP_001171111; NP_001171112; NP_001171113; NP_001171114; NP_001171115; NP_004384
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DAG1 yw DAG1 a elwir hefyd yn Dystroglycan a Dystroglycan 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3p21.31.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DAG1.

A3a
DAG
AGRNR
156DAG
MDDGA9
MDDGC7
MDDGC9

Llyfryddiaeth[golygu | golygu cod]

"A role for dystroglycan in the pathophysiology of acute leukemic cells. ". Life Sci. 2017. PMID 28591567.
"DAG1 mutations associated with asymptomatic hyperCKemia and hypoglycosylation of α-dystroglycan. ". Neurology. 2015. PMID 25503980.
"Reduction of α-dystroglycan expression is correlated with poor prognosis in glioma. ". Tumour Biol. 2014. PMID 25139094.
"Dystroglycan depletion inhibits the functions of differentiated HL-60 cells. ". Biochem Biophys Res Commun. 2014. PMID 24792180.
"Hypoglycosylation of dystroglycan due to T192M mutation: a molecular insight behind the fact.". Gene. 2014. PMID 24361964.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] DAG1 - Cronfa NCBI

[1]

[2]