DACH1

DACH1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1L8R
Dynodwyr
Cyfenwau	DACH1, DACH, dachshund family transcription factor 1
Dynodwyr allanol	OMIM: 603803 HomoloGene: 7288 GeneCards: DACH1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0000983 RNA polymerase II general transcription initiation factor activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • cnewyllyn cell • transcription regulator complex Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • negative regulation of transcription by competitive promoter binding • RNA polymerase II preinitiation complex assembly • GO:1901227 negative regulation of transcription by RNA polymerase II • respiratory gaseous exchange by respiratory system • transcription, DNA-templated • development of primary female sexual characteristics • negative regulation of cell migration • regulation of nuclear cell cycle DNA replication • negative regulation of cell proliferation involved in contact inhibition • cell population proliferation • GO:0045996 negative regulation of transcription, DNA-templated • negative regulation of fibroblast proliferation • negative regulation of DNA biosynthetic process • suckling behavior • multicellular organism development • transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1602	n/a
Ensembl	ENSG00000276644	n/a
UniProt	Q9UI36	n/a
RefSeq (mRNA)	NM_004392 NM_080759 NM_080760 NM_001366712	n/a
RefSeq (protein)	NP_004383 NP_542937 NP_542938 NP_001353641	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn DACH1 yw DACH1 a elwir hefyd yn Dachshund family transcription factor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 13, band 13q21.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn DACH1.

• DACH

Llyfryddiaeth

• "[Knockdown of dachshund homolog 1 (DACH1) promotes cell apoptosis and inhibits the invasion and migration abilities of Capan-1 pancreatic cancer cells]. ". Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016. PMID 27609579.
• "Inhibition of DACH1 activity by short hairpin RNA represses cell proliferation and tumor invasion in pancreatic cancer. ". Oncol Rep. 2016. PMID 27278537.
• "DACH1 is a novel predictive and prognostic biomarker in hepatocellular carcinoma as a negative regulator of Wnt/β-catenin signaling. ". Oncotarget. 2015. PMID 25940701.
• "The endogenous cell-fate factor dachshund restrains prostate epithelial cell migration via repression of cytokine secretion via a cxcl signaling module. ". Cancer Res. 2015. PMID 25769723.
• "Silencing DACH1 promotes esophageal cancer growth by inhibiting TGF-β signaling.". PLoS One. 2014. PMID 24743895.