CYP2D6

CYP2D6
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2F9Q, 3QM4, 3TBG, 3TDA, 4WNT, 4WNU, 4WNV, 4WNW, 4XRY, 4XRZ
Dynodwyr
Cyfenwau	CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1, cytochrome P450 family 2 subfamily D member 6, Cytochrome P450 2D6
Dynodwyr allanol	OMIM: 124030 HomoloGene: 133550 GeneCards: CYP2D6
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • iron ion binding • metal ion binding • heme binding • GO:0050602 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • oxidoreductase activity • aromatase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • steroid hydroxylase activity • monooxygenase activity Cydrannau o'r gell • organelle membrane • endoplasmic reticulum membrane • bilen • intracellular membrane-bounded organelle • Reticwlwm endoplasmig • mitocondria • cytoplasm Prosesau biolegol • steroid metabolic process • alkaloid metabolic process • coumarin metabolic process • lipid metabolism • isoquinoline alkaloid metabolic process • GO:1900774, GO:1900783, GO:1900795, GO:1901084, GO:1900780, GO:1900777, GO:1900771, GO:1901014, GO:1902180, GO:1900987, GO:1900990 alkaloid catabolic process • oxidative demethylation • heterocycle metabolic process • negative regulation of binding • monoterpenoid metabolic process • xenobiotic metabolic process • arachidonic acid metabolic process • negative regulation of cellular organofluorine metabolic process • long-chain fatty acid biosynthetic process • organic acid metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1565	n/a
Ensembl	ENSG00000100197 ENSG00000275211 ENSG00000280905 ENSG00000282966 ENSG00000283284 ENSG00000272532	n/a
UniProt	P10635	n/a
RefSeq (mRNA)	NM_000106 NM_001025161	n/a
RefSeq (protein)	NP_000097 NP_001020332	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CYP2D6 yw CYP2D6 a elwir hefyd yn Cytochrome P450 family 2 subfamily D member 6 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 22, band 22q13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CYP2D6.

• CPD6
• CYP2D
• CYP2DL1
• CYPIID6
• P450C2D
• P450DB1
• CYP2D7AP
• CYP2D7BP
• CYP2D7P2
• CYP2D8P2
• P450-DB1

Llyfryddiaeth

• "Inference of the Genetic Polymorphisms of CYP2D6 in Six Subtribes of the Malaysian Orang Asli from Whole-Genome Sequencing Data. ". Genet Test Mol Biomarkers. 2017. PMID 28525288.
• "Effect of 22 CYP2D6 variants found in the Chinese population on tolterodine metabolism in vitro. ". Chem Biol Interact. 2017. PMID 28087463.
• "Significant Effect of Polymorphisms in CYP2D6on Response to Tamoxifen Therapy for Breast Cancer: A Prospective Multicenter Study. ". Clin Cancer Res. 2017. PMID 27797974.
• "Association between Functional CYP2D6 Polymorphisms and Susceptibility to Autoimmune Diseases: A Meta-Analysis. ". Immunol Invest. 2017. PMID 27749127.
• "Influences of CYP2D6*10 polymorphisms on the pharmacokinetics of iloperidone and its metabolites in Chinese patients with schizophrenia: a population pharmacokinetic analysis.". Acta Pharmacol Sin. 2016. PMID 27665849.