CYP2C9

CYP2C9
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1OG2, 1OG5, 1R9O, 4NZ2
Dynodwyr
Cyfenwau	CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9, cytochrome P450 family 2 subfamily C member 9, Cytochrome P450 2C9, P450-2C9
Dynodwyr allanol	OMIM: 601130 HomoloGene: 133566 GeneCards: CYP2C9
EC number	1.14.14.51
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • iron ion binding • arachidonic acid epoxygenase activity • metal ion binding • steroid hydroxylase activity • caffeine oxidase activity • heme binding • GO:0050602 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • oxidoreductase activity • monooxygenase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Cydrannau o'r gell • organelle membrane • endoplasmic reticulum membrane • bilen • intracellular membrane-bounded organelle • Reticwlwm endoplasmig • cytoplasm Prosesau biolegol • steroid metabolic process • lipid metabolism • cellular amide metabolic process • epoxygenase P450 pathway • monocarboxylic acid metabolic process • oxidative demethylation • omega-hydroxylase P450 pathway • monoterpenoid metabolic process • xenobiotic metabolic process • urea metabolic process • long-chain fatty acid biosynthetic process • organic acid metabolic process • estrogen metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1559	n/a
Ensembl	ENSG00000138109	n/a
UniProt	P11712	n/a
RefSeq (mRNA)	NM_000771	n/a
RefSeq (protein)	NP_000762	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CYP2C9 yw CYP2C9 a elwir hefyd yn Cytochrome P450 family 2 subfamily C member 9 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q23.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CYP2C9.

• CPC9
• CYP2C
• CYP2C10
• CYPIIC9
• P450IIC9

Llyfryddiaeth

• "Structural Basis of Single-Nucleotide Polymorphisms in Cytochrome P450 2C9. ". Biochemistry. 2017. PMID 28972767.
• "Delayed de-induction of CYP2C9 compared to CYP3A after discontinuation of rifampicin: Report of two cases
. ". Int J Clin Pharmacol Ther. 2017. PMID 28157069.
• "CYP2C9 Genotypes Modify Benzodiazepine-Related Fall Risk: Original Results From Three Studies With Meta-Analysis. ". J Am Med Dir Assoc. 2017. PMID 27889507.
• "Quantitative Assessment of CYP2C9 Genetic Polymorphisms Effect on the Oral Clearance of S-Warfarin in Healthy Subjects. ". Mol Diagn Ther. 2017. PMID 27878474.
• "Effects of CYP2C9 genetic polymorphisms on the pharmacokinetics of celecoxib and its carboxylic acid metabolite.". Arch Pharm Res. 2017. PMID 27864660.