CYP1A2

CYP1A2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2HI4
Dynodwyr
Cyfenwau	CYP1A2, CP12, P3-450, P450(PA), cytochrome P450 family 1 subfamily A member 2, Cytochrome P450 1A2, CYPIA2
Dynodwyr allanol	OMIM: 124060 HomoloGene: 68082 GeneCards: CYP1A2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • iron ion binding • demethylase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • metal ion binding • caffeine oxidase activity • heme binding • GO:0050602 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • enzyme binding • oxidoreductase activity • aromatase activity • electron transfer activity • monooxygenase activity Cydrannau o'r gell • organelle membrane • endoplasmic reticulum membrane • intracellular membrane-bounded organelle • bilen • Reticwlwm endoplasmig Prosesau biolegol • response to immobilization stress • toxin metabolic process • steroid metabolic process • response to estradiol • alkaloid metabolic process • GO:1904578 response to organic cyclic compound • lung development • lipid metabolism • epoxygenase P450 pathway • cellular response to cadmium ion • post-embryonic development • monocarboxylic acid metabolic process • response to organic substance • oxidative demethylation • response to lipopolysaccharide • methylation • steroid catabolic process • omega-hydroxylase P450 pathway • dibenzo-p-dioxin metabolic process • heterocycle metabolic process • Resbiradaeth cellog • cellular aromatic compound metabolic process • regulation of gene expression • hydrogen peroxide biosynthetic process • monoterpenoid metabolic process • xenobiotic metabolic process • porphyrin-containing compound metabolic process • toxin biosynthetic process • cellular response to copper ion • electron transport chain • long-chain fatty acid biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1544	n/a
Ensembl	ENSG00000140505	n/a
UniProt	P05177	n/a
RefSeq (mRNA)	NM_000761	n/a
RefSeq (protein)	NP_000752	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CYP1A2 yw CYP1A2 a elwir hefyd yn Cytochrome P450 family 1 subfamily A member 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q24.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CYP1A2.

• CP12
• CYPIA2
• P3-450
• P450(PA)

Llyfryddiaeth

• "Genetic polymorphisms of cytochrome P450-1A2 (CYP1A2) among Emiratis. ". PLoS One. 2017. PMID 28934216.
• "CYP1A2 Genotype Variations Do Not Modify the Benefits and Drawbacks of Caffeine during Exercise: A Pilot Study. ". Nutrients. 2017. PMID 28287486.
• "Meta-analysis of correlation between the CYP1A2 -3860 G > A polymorphism and lung cancer risk. ". Genet Mol Res. 2016. PMID 27323197.
• "Dose validation of PhIP hair level as a biomarker of heterocyclic aromatic amines exposure: a feeding study. ". Carcinogenesis. 2016. PMID 27207666.
• "Cigarette smoking has a differential effect on the plasma level of clozapine in Taiwanese schizophrenic patients associated with the CYP1A2 gene -163A/C single nucleotide polymorphism.". Psychiatr Genet. 2016. PMID 27203225.