CYP11B2

CYP11B2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4DVQ, 4FDH, 4ZGX
Dynodwyr
Cyfenwau	CYP11B2, ALDOS, CPN2, CYP11B, CYP11BL, CYPXIB2, P-450C18, P450C18, P450aldo, cytochrome P450 family 11 subfamily B member 2
Dynodwyr allanol	OMIM: 124080 HomoloGene: 106948 GeneCards: CYP11B2
EC number	1.14.15.4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • iron ion binding • corticosterone 18-monooxygenase activity • metal ion binding • monooxygenase activity • heme binding • GO:0050602 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • oxidoreductase activity • steroid 11-beta-monooxygenase activity • steroid hydroxylase activity Cydrannau o'r gell • mitochondrial membranes • bilen • mitocondria • mitochondrial inner membrane Prosesau biolegol • lipid metabolism • aldosterone biosynthetic process • cortisol biosynthetic process • C21-steroid hormone biosynthetic process • cellular response to hormone stimulus • potassium ion homeostasis • mineralocorticoid biosynthetic process • regulation of blood volume by renal aldosterone • renal water homeostasis • sterol metabolic process • sodium ion homeostasis • cellular response to potassium ion • steroid biosynthetic process • steroid metabolic process • glucocorticoid biosynthetic process • cholesterol metabolic process • cellular response to peptide hormone stimulus • cortisol metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1585	n/a
Ensembl	ENSG00000179142	n/a
UniProt	P19099	n/a
RefSeq (mRNA)	NM_000498	n/a
RefSeq (protein)	NP_000489	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CYP11B2 yw CYP11B2 a elwir hefyd yn Cytochrome P450 family 11 subfamily B member 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8q24.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CYP11B2.

• CPN2
• ALDOS
• CYP11B
• CYP11BL
• CYPXIB2
• P450C18
• P-450C18
• P450aldo

Llyfryddiaeth

• "A novel haplotype of low-frequency variants in the aldosterone synthase gene among northern Han Chinese with essential hypertension. ". Medicine (Baltimore). 2017. PMID 28953657.
• "Prognostic Value of Different Allelic Polymorphism of Aldosterone Synthase Receptor in a Congestive Heart Failure European Continental Ancestry Population. ". Arch Med Res. 2017. PMID 28625318.
• "Age-Related Autonomous Aldosteronism. ". Circulation. 2017. PMID 28566337.
• "The impact of the clinical CYP11B2 mutation V386A strongly depends on the enzyme's genetic background. ". Endocr J. 2017. PMID 28190867.
• "Haplotype association and synergistic effect of human aldosterone synthase (CYP11B2) gene polymorphisms causing susceptibility to essential hypertension in Indian patients.". Clin Exp Hypertens. 2016. PMID 27935319.